Changing paradigms in radiobiology Journal Articles

abstract

• The last 25 years have seen a major shift in emphasis in the field of radiobiology from a DNA-centric view of how radiation damage occurs to a much more biological view that appreciates the importance of macro-and micro-environments, hierarchical organization, underlying genetics, evolution, adaptation and signaling at all levels from atoms to ecosystems. The new view incorporates concepts of hormesis, nonlinear systems, bioenergy field theory, uncertainty and homeodynamics. While the mechanisms underlying these effects and responses are still far from clear, it is very apparent that their implications are much wider than the field of radiobiology. This reflection discusses the changing views and considers how they are influencing thought in environmental and medical science and systems biology.

authors

• Mothersill, Carmel Emelia
• Seymour, Colin

status

• published 

publication date

• April 2012

has subject area

• Biological Evolution (MeSH)
• Bystander Effect (MeSH)
• DNA Damage (MeSH)
• Dose-Response Relationship, Radiation (MeSH)
• Genomic Instability (MeSH)
• Models, Biological (MeSH)
• Oncology & Carcinogenesis (Science Metrix)
• Radiation Protection (MeSH)
• Radiobiology (MeSH)
• Radiotherapy (MeSH)
• Systems Biology (MeSH)

published in

• MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS  Journal

keywords

• Biological Evolution
• Bystander Effect
• DNA Damage
• Dose-Response Relationship, Radiation
• Genomic Instability
• Models, Biological
• Radiation Protection
• Radiobiology
• Radiotherapy
• Systems Biology

Digital Object Identifier (DOI)

• 10.1016/j.mrrev.2011.12.007

PubMed ID

• 22273762

start page

• 85

end page

• 95

volume

• 750

issue

• 2