Journal article
NR1D1 Recruitment to Sites of DNA Damage Inhibits Repair and Is Associated with Chemosensitivity of Breast Cancer
Abstract
DNA repair capacity is critical for survival of cancer cells upon therapeutic DNA damage and thus is an important determinant of susceptibility to chemotherapy in cancer patients. In this study, we identified a novel function of nuclear receptor NR1D1 in DNA repair, which enhanced chemosensitivity in breast cancer cells. NR1D1 inhibited both nonhomologous end joining and homologous recombination double-strand breaks repair, and delayed the …
Authors
Ka N-L; Na T-Y; Na H; Lee M-H; Park H-S; Hwang S; Kim IY; Seong JK; Lee M-O
Journal
Cancer Research, Vol. 77, No. 9, pp. 2453–2463
Publisher
American Association for Cancer Research (AACR)
Publication Date
May 1, 2017
DOI
10.1158/0008-5472.can-16-2099
ISSN
0008-5472