Journal article
Deficient base excision repair of oxidative DNA damage induced by methylene blue plus visible light in xeroderma pigmentosum group C fibroblasts
Abstract
Methylene blue plus visible light (MB+VL) results in oxidative DNA damage, producing predominantly 7,8-dihydroxy-8-oxoguanine and other single base modifications that are repaired by base excision repair (BER). AdCA17 is non-replicating recombinant human adenovirus that infects human cells and expresses the beta-galactosidase (beta-gal) reporter gene. We have examined host cell reactivation (HCR) of beta-gal activity for (MB+VL)-treated AdCA17 …
Authors
Kassam SN; Rainbow AJ
Journal
Biochemical and Biophysical Research Communications, Vol. 359, No. 4, pp. 1004–1009
Publisher
Elsevier
Publication Date
August 2007
DOI
10.1016/j.bbrc.2007.06.005
ISSN
0006-291X