Journal article
DNA damage in rats after treatment with methylphenidate
Abstract
BACKGROUND: Methylphenidate (MPH) is a widely prescribed psychostimulant for the treatment of attention-deficit hyperactivity disorder (ADHD). Recently, some studies have addressed the genotoxic potential of the MPH, but the results have been contradictory. Hence, the present study aimed to investigate the index of cerebral and peripheral DNA damage in young and adult rats after acute and chronic MPH exposure.
METHODS: We used (1) single cell …
Authors
Andreazza AC; Frey BN; Valvassori SS; Zanotto C; Gomes KM; Comim CM; Cassini C; Stertz L; Ribeiro LC; Quevedo J
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 31, No. 6, pp. 1282–1288
Publisher
Elsevier
Publication Date
August 2007
DOI
10.1016/j.pnpbp.2007.05.012
ISSN
0278-5846