Journal article
Effects of mood stabilizers on DNA damage in an animal model of mania
Abstract
OBJECTIVE: Recent studies have suggested that oxidative stress and DNA damage may play a role in the pathophysiology of bipolar disorder (BD). We investigated the effects of the mood stabilizers lithium and valproate on amphetamine-induced DNA damage in an animal model of mania and their correlation with oxidative stress markers.
METHODS: In the first experiment (reversal model), we treated adult male Wistar rats with D-amphetamine (AMPH) or …
Authors
Andreazza AC; Kauer-Sant’Anna M; Frey BN; Stertz L; Zanotto C; Ribeiro L; Giasson K; Valvassori SS; Réus GZ; Salvador M
Journal
Journal of Psychiatry and Neuroscience, Vol. 33, No. 6, pp. 516–524
Publication Date
November 2008
DOI
10.1503/jpn.0849
ISSN
1180-4882