Journal article
DNA Damage Repair in Huntington's Disease and Other Neurodegenerative Diseases
Abstract
Recent genome-wide association studies of Huntington's disease (HD) primarily highlighted genes involved in DNA damage repair mechanisms as modifiers of age at onset and disease severity, consistent with evidence that more DNA repair genes are being implicated in late age-onset neurodegenerative diseases. This provides an exciting opportunity to advance therapeutic development in HD, as these pathways have already been under intense …
Authors
Maiuri T; Suart CE; Hung CLK; Graham KJ; Bazan CAB; Truant R
Journal
Neurotherapeutics, Vol. 16, No. 4, pp. 948–956
Publisher
Elsevier
Publication Date
October 2019
DOI
10.1007/s13311-019-00768-7
ISSN
1933-7213