Journal article
Recognition and repair of chemically heterogeneous structures at DNA ends
Abstract
Exposure to environmental toxicants and stressors, radiation, pharmaceutical drugs, inflammation, cellular respiration, and routine DNA metabolism all lead to the production of cytotoxic DNA strand breaks. Akin to splintered wood, DNA breaks are not "clean." Rather, DNA breaks typically lack DNA 5'-phosphate and 3'-hydroxyl moieties required for DNA synthesis and DNA ligation. Failure to resolve damage at DNA ends can lead to abnormal DNA …
Authors
Andres SN; Schellenberg MJ; Wallace BD; Tumbale P; Williams RS
Journal
Environmental and Molecular Mutagenesis, Vol. 56, No. 1, pp. 1–21
Publisher
Wiley
Publication Date
January 2015
DOI
10.1002/em.21892
ISSN
0893-6692