Journal article
Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102
Abstract
The hepatocyte growth factor (HGF)/Met signalling pathway is up-regulated in many cancers, with downstream mediators playing a role in DNA double strand break repair. Previous studies have shown increased radiosensitization of tumours through modulation of Met signalling by genetic methods. We investigated the effects of the anti-HGF monoclonal antibody, AMG102, on the response to ionizing radiation in a model of glioblastoma multiforme in …
Authors
Buchanan IM; Scott T; Tandle AT; Burgan WE; Burgess TL; Tofilon PJ; Camphausen K
Journal
Journal of Cellular and Molecular Medicine, Vol. 15, No. 9, pp. 1999–2006
Publisher
Wiley
Publication Date
September 2011
DOI
10.1111/j.1582-4934.2010.01122.x
ISSN
1582-1838