Recombinant Fusion Proteins Concept

subject area of

• A Barbourin-albumin Fusion Protein that Is Slowly Cleared In Vivo Retains the Ability to Inhibit Platelet Aggregation In Vitro  Academic Article
• A Novel Approach to Tumor Suppression with Microencapsulated Recombinant Cells  Academic Article
• A double recombinant adenovirus expressing the costimulatory molecule B7-1 (murine) and human IL-2 induces complete tumor regression in a murine breast adenocarcinoma model.  Academic Article
• A hydrophobic sequence at position 313-316 (Leu-Ala-Phe-Trp) in the fifth domain of apolipoprotein H (β2-glycoprotein I) is crucial for cardiolipin binding  Academic Article
• A long-lasting, plasmin-activatable thrombin inhibitor aids clot lysis in vitro and does not promote bleeding in vivo  Academic Article
• A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL.  Academic Article
• A phase I trial of ANG1/2-Tie2 inhibitor trebaninib (AMG386) and temsirolimus in advanced solid tumors (PJC008/NCI♯9041)  Academic Article
• A synthetic luxCDABE gene cluster optimized for expression in high-GC bacteria  Academic Article
• A von Willebrand factor fragment containing the D'D3 domains is sufficient to stabilize coagulation factor VIII in mice  Academic Article
• ARMMs as a versatile platform for intracellular delivery of macromolecules  Academic Article
• Abundant expression of herpes simplex virus glycoprotein gB using an adenovirus vector  Academic Article
• Active site labeling of the gentamicin resistance enzyme AAC(6')-APH(2") by the lipid kinase inhibitor wortmannin  Academic Article
• Addition of a sequence from α2-antiplasmin transforms human serum albumin into a blood clot component that speeds clot lysis  Academic Article
• Adenovirus-mediated cytokine gene transfer at tissue sites. Overexpression of IL-6 induces lymphocytic hyperplasia in the lung.  Academic Article
• Amino acid substitutions of the P2 residue of human antithrombin that either enhance or impair function  Academic Article
• An Ultrasensitive Bacterial Motor Revealed by Monitoring Signaling Proteins in Single Cells  Academic Article
• An engineered right-handed coiled coil domain imparts extreme thermostability to the KcsA channel  Academic Article
• Antigen Interaction and Heat Inactivation Expose New Epitopes on Human IgE  Academic Article
• Assembly of Bcl-2 into microsomal and outer mitochondrial membranes.  Academic Article
• Autoregulation of the Drosophila disconnected Gene in the Developing Visual System  Academic Article
• Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.  Academic Article
• Binding Site Determinants for the LysR-Type Transcriptional Regulator PcaQ in the Legume Endosymbiont Sinorhizobium meliloti  Academic Article
• Biologic survival.  Academic Article
• Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres  Academic Article
• Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73  Academic Article
• Characterization and epitope mapping of a human monoclonal antibody reactive with the envelope glycoprotein of human immunodeficiency virus.  Academic Article
• Characterization of a long-acting recombinant human serum albumin-atrial natriuretic factor (ANF) expressed in Pichia pastoris  Academic Article
• Chimeric Structure of the NAD(P)+- and NADP+-dependent Malic Enzymes ofRhizobium (Sinorhizobium) meliloti  Academic Article
• Cloning and Some Novel Characteristics of Mitochondrial Hsp70 from Chinese Hamster Cells  Academic Article
• Cloning of Human Anti-lgE Autoantibodies and Their Role in the Regulation of IgE Synthesis  Conference Paper
• Combined administration of barbourin–albumin and hirudin–albumin fusion proteins limits fibrin(ogen) deposition on the rabbit balloon-injured aorta  Academic Article
• Community-based evaluation of etanercept in patients with rheumatoid arthritis.  Academic Article
• Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress  Academic Article
• Construction of a Double Recombinant Adenovirus Vector Expressing a Heterodimeric Cytokine: In Vitro and In Vivo Production of Biologically Active Interleukin-12  Academic Article
• Continuous prophylaxis with recombinant factor IX Fc fusion protein and conventional recombinant factor IX products: comparisons of efficacy and weekly factor consumption  Academic Article
• Cross-chimeric analysis of selectivity of secretin and VPAC(1) receptor activation.  Academic Article
• Crystal Structure of the Minimalist Max-E47 Protein Chimera  Academic Article
• Customized Viral Immunotherapy for HPV-Associated Cancer  Academic Article
• Delivery of human factor IX in mice by encapsulated recombinant myoblasts: a novel approach towards allogeneic gene therapy of hemophilia B.  Academic Article
• Demarcation of Stable Subpopulations within the Pluripotent hESC Compartment  Academic Article
• Design and baseline characteristics of participants in the R esearching cardiovascular E vents with a W eekly IN cretin in D iabetes ( REWIND ) trial on the cardiovascular effects of dulaglutide  Academic Article
• Detection of antibodies reacting with the antithetical duffy blood group antigens Fya and Fyb using recombinant fusion proteins containing the duffy extracellular domain  Academic Article
• Determinants for calcitonin analog interaction with the calcitonin receptor N-terminus and transmembrane-loop regions.  Academic Article
• Determination of the Topology of the Hydrophobic Segment of Mammalian Diacylglycerol Kinase Epsilon in a Cell Membrane and Its Relationship to Predictions from Modeling  Academic Article
• Determination of the native form of FadD, the Escherichia coli fatty acyl-CoA synthetase, and characterization of limited proteolysis by outer membrane protease OmpT  Academic Article
• Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.  Academic Article
• Disparate Subcellular Localization Patterns of Pseudomonas aeruginosa Type IV Pilus ATPases Involved in Twitching Motility  Academic Article
• Disruption of the coordinate expression of muscle genes in a transfected BC3H1 myoblast cell line producing a low level of the adenovirus E1A transforming protein  Academic Article
• Dystrophin isoforms Dp71 and Dp427 have distinct roles in myogenic cells  Academic Article
• Effect of a thrombopoietin receptor agonist on use of intravenous immune globulin in patients with immune thrombocytopenia  Academic Article
• Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits  Conference Paper
• Effects of the Once-Weekly Glucagon-Like Peptide-1 Receptor Agonist Dulaglutide on Ambulatory Blood Pressure and Heart Rate in Patients With Type 2 Diabetes Mellitus  Academic Article
• Efficacy Outcomes in Patients Using Alefacept in the AWARE Study  Academic Article
• Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches.  Academic Article
• Elicitation of utility scores in Canada for immune thrombocytopenia treated with romiplostim or watch and rescue  Academic Article
• Eltrombopag for the treatment of chronic idiopathic (immune) thrombocytopenic purpura (ITP)  Academic Article
• Engineered human Tmpk fused with truncated cell-surface markers: versatile cell-fate control safety cassettes  Academic Article
• Enhancement of dendritic cell tolerogenicity by genetic modification using adenoviral vectors encoding cDNA for TGFβ1  Academic Article
• Expression and spectroscopic characterization of a large fragment of the μ-opioid receptor  Academic Article
• Expression of the HSV-2 ribonucleotide reductase subunits in adenovirus vectors or stably transformed cells: Restoration of enzymatic activity by reassociation of enzyme subunits in the absence of other HSV proteins  Academic Article
• Factor VII deficiency caused by a structural variant N57D of the first epidermal growth factor domain.  Academic Article
• Factor VIIa gets even bigger  Academic Article
• Factors that contribute to the immmunogenicity of therapeutic recombinant human proteins  Academic Article
• Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition  Academic Article
• Fusion to Albumin as a Means to Slow the Clearance of Small Therapeutic Proteins Using the Pichia pastoris Expression System: A Case Study  Academic Article
• Fusion to Human Serum Albumin Extends the Circulatory Half-Life and Duration of Antithrombotic Action of the Kunitz Protease Inhibitor Domain of Protease Nexin 2  Academic Article
• Generation of experimental allergic airways inflammation in the absence of draining lymph nodes  Academic Article
• Genetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila model  Academic Article
• Helper virus-free HSV-1 vectors packaged both in the presence of VSV G protein and in the absence of HSV-1 glycoprotein B support gene transfer into neurons in the rat striatum  Academic Article
• Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs.  Academic Article
• High Mobility of Bicoid Captured by Fluorescence Correlation Spectroscopy: Implication for the Rapid Establishment of Its Gradient  Academic Article
• Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells  Academic Article
• IL-12 gene therapy protects mice in lethal Klebsiella pneumonia.  Academic Article
• INHIBITION OF THROMBIN BY HIRUDIN GENETICALLY FUSED TO WILD-TYPE OR MUTANT ANTITHROMBIN  Academic Article
• IRR: a novel member of the insulin receptor family.  Conference Paper
• Identification and Functional Characterization of a Novel Nuclear Localization Signal Present in the Yeast Nab2 Poly(A)+RNA Binding Protein  Academic Article
• Identification and characterization of a small modular domain in the herpes simplex virus host shutoff protein sufficient for interaction with VP16.  Academic Article
• Identification and functional analysis ofCITED2 mutations in patients with congenital heart defects  Academic Article
• Identification of a domain of the herpes simplex virus trans-activator Vmw65 required for protein-DNA complex formation through the use of protein A fusion proteins.  Academic Article
• Immuno-gene therapy of established prostate tumors using chimeric receptor-redirected human lymphocytes.  Academic Article
• Immunotherapies in Dermatologic Disorders  Academic Article
• Import of precursor proteins into mitochondria: site of polypeptide unfolding.  Academic Article
• In VivoFormation of Protein Based Aqueous Microcompartments  Academic Article
• Incorporation of albumin fusion proteins into fibrin clots in vitro and in vivo: comparison of different fusion motifs recognized by factor XIIIa  Academic Article
• Indirect comparisons of efficacy and weekly factor consumption during continuous prophylaxis with recombinant factor VIII Fc fusion protein and conventional recombinant factor VIII products  Academic Article
• Induction of an immune response to transmissible gastroenteritis coronavirus using vectors with enteric tropism.  Academic Article
• Induction of hTERT Expression and Telomerase Activity by Estrogens in Human Ovary Epithelium Cells  Academic Article
• Influence of membrane anchoring and cytoplasmic domains on the fusogenic activity of vesicular stomatitis virus glycoprotein G.  Academic Article
• Insertion of a Retrotransposon inMbpDisrupts mRNA Splicing and Myelination in a New Mutant Rat  Academic Article
• Insulin acutely decreases hepatic fatty acid synthase activity  Academic Article
• Interaction between oncostatin M, interleukin 1 and prostaglandin E2 in induction of IL-6 expression in human fibroblasts  Academic Article
• Interaction of Cyclin-dependent Kinase 5 (Cdk5) and Neuronal Cdk5 Activator in Bovine Brain  Academic Article
• Interactions between flagellar and type III secretion proteins in Chlamydia pneumoniae  Academic Article
• Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells  Academic Article
• Interspecies exchange mutagenesis of the first epidermal growth factor-like domain of human factor VII  Academic Article
• Intracellular Trafficking of CD23: Differential Regulation in Humans and Mice by Both Extracellular and Intracellular Exons  Academic Article
• Intracellular events determine the fate of antithrombin Utah.  Academic Article
• Isolation and Characterization of XKaiso, a Transcriptional Repressor That Associates with the Catenin Xp120ctninXenopus laevis  Academic Article
• Kaiso regulates Znf131-mediated transcriptional activation  Academic Article
• Lengthened G1 Phase Indicates Differentiation Status in Human Embryonic Stem Cells  Academic Article
• Lifeact cannot visualize some forms of stress-induced twisted f-actin  Academic Article
• Lineage, migration, and morphogenesis of longitudinal glia in the Drosophila CNS as revealed by a molecular lineage marker  Academic Article
• Linear Free Energy Relationship Analysis of Transition State Mimicry by 3-Deoxy-d-arabino-heptulosonate-7-phosphate (DAHP) Oxime, a DAHP Synthase Inhibitor and Phosphate Mimic  Academic Article
• Long-acting recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in children  Academic Article
• MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function  Academic Article
• Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα  Academic Article
• Mechanistic Studies on Norcoclaurine Synthase of Benzylisoquinoline Alkaloid Biosynthesis:  An Enzymatic Pictet−Spengler Reaction†  Academic Article
• Membrane anchoring domain of herpes simplex virus glycoprotein gB is sufficient for nuclear envelope localization.  Academic Article
• MicroRNA-145 Targeted Therapy Reduces Atherosclerosis  Conference Paper
• Mitochondrial precursor protein. Effects of 70-kilodalton heat shock protein on polypeptide folding, aggregation, and import competence.  Academic Article
• Molecular and functional characterization of a partial cDNA encoding a novel chicken brain melatonin receptor  Academic Article
• Monovalent Fc receptor blockade by an anti-Fc  receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity  Academic Article
• Mouse NGF promoter upstream sequences do not affect gene expression in mouse fibroblasts  Academic Article
• Murine β-galactosidase stability is not dependent on temperature or protective protein/cathepsin A  Academic Article
• NADP+ -dependent malic enzyme of Rhizobium meliloti.  Academic Article
• NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression  Academic Article
• Nail Psoriasis and Biologics  Academic Article
• Nervous system modification by transplants and gene transfer  Academic Article
• New treatments for idiopathic thrombocytopenic purpura: rethinking old hypotheses  Academic Article
• Novel targeted therapies for eosinophilic disorders  Academic Article
• Nuclear Import of Cdk/Cyclin Complexes: Identification of Distinct Mechanisms for Import of Cdk2/Cyclin E and Cdc2/Cyclin B1  Academic Article
• Nudeocytoplasmic shuttling by protein nuclear import factors  Academic Article
• Orphan Nuclear Hormone Receptor RevErbα Modulates Expression from the Promoter of the Hydratase-dehydrogenase Gene by Inhibiting Peroxisome Proliferator-activated Receptor α-Dependent Transactivation  Academic Article
• Over-expression of CUG- or AUG-initiated Forms of Basic Fibroblast Growth Factor in Cardiac Myocytes Results in Similar Effects on Mitosis and Protein Synthesis but Distinct Nuclear Morphologies  Academic Article
• Phage Display of the Serpin Alpha-1 Proteinase Inhibitor Randomized at Consecutive Residues in the Reactive Centre Loop and Biopanned with or without Thrombin  Academic Article
• Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity  Academic Article
• Platelet count or bleeding as the outcome in ITP trials?  Academic Article
• Polyomavirus large T-antigen binds the ‘pRb related’ protein p130 through sequences in conserved region 2  Academic Article
• Positioning new treatments in the management of immune thrombocytopenia  Academic Article
• Potent antithrombin activity and delayed clearance from the circulation characterize recombinant hirudin genetically fused to albumin.  Academic Article
• Practical Understanding of Mean Percent Psoriasis Area and Severity Index Reduction for Biologics  Academic Article
• Prolonged in vivo anticoagulant activity of a hirudin–albumin fusion protein secreted from Pichia pastoris  Academic Article
• Protein mobility in the cytoplasm of Escherichia coli.  Academic Article
• Purification and characterization of VanR and the cytosolic domain of VanS: A two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4147  Academic Article
• Purification of Plant-Derived Antibodies through Direct Immobilization of Affinity Ligands on Cellulose  Academic Article
• Purification of an elastin-like fusion protein by microfiltration  Academic Article
• Purification of chimeric heavy chain monoclonal antibody EG2-hFc using hydrophobic interaction membrane chromatography: An alternative to protein-A affinity chromatography  Academic Article
• Randomized, International Study of Cyclosporine Microemulsion Absorption Profiling in Renal Transplantation with Basiliximab Immunoprophylaxis  Academic Article
• Ranibizumab vs. aflibercept for wet age-related macular degeneration: network meta-analysis to understand the value of reduced frequency dosing  Academic Article
• Recombinant albumins containing additional peptide sequences smaller than barbourin retain the ability of barbourin-albumin to inhibit platelet aggregation  Academic Article
• Recombinant human adenoviruses containing hybrid adenovirus type 5 (Ad5)/Ad12 E1A genes: characterization of hybrid E1A proteins and analysis of transforming activity and host range.  Academic Article
• Reduction of thrombus size in murine models of thrombosis following administration of recombinant α1-proteinase inhibitor mutant proteins  Academic Article
• Regulated expression of plant tRNA genes by the prokaryotic tet and lac repressors.  Academic Article
• Regulation of katF and katE in Escherichia coli K-12 by weak acids.  Academic Article
• Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1, and IL-6.  Academic Article
• Relative Contribution of Endogenous Neurotrophins in Hippocampal Long-Term Potentiation  Academic Article
• Requirement for a non-specific glycoprotein cytoplasmic domain sequence to drive efficient budding of vesicular stomatitis virus  Academic Article
• Role of the membrane anchoring and cytoplasmic domains in intracellular transport and localization of viral glycoproteins  Academic Article
• RpoS-Regulated Genes of Escherichia coli Identified by Random lacZ Fusion Mutagenesis  Academic Article
• Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti–IL-5 receptor α antibody, in a phase I study of subjects with mild asthma  Academic Article
• Selective Inhibition of Inward Rectifier K + Channels (Kir2.1 or Kir2.2) Abolishes Protection by Ischemic Preconditioning in Rabbit Ventricular Cardiomyocytes  Academic Article
• Self-Cleavable Stimulus Responsive Tags for Protein Purification without Chromatography  Academic Article
• Sirolimus and low-dose tacrolimus with antibody induction in kidney transplantation: preliminary results of a pilot study  Conference Paper
• Smad3 Null Mice Develop Airspace Enlargement and Are Resistant to TGF- -Mediated Pulmonary Fibrosis  Academic Article
• Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation  Academic Article
• Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels  Academic Article
• Stationary Phase Expression of a NovelEscherichia coliOuter Membrane Lipoprotein and Its Relationship with Mammalian Apolipoprotein D  Academic Article
• Stress-mediated signaling in PC12 cells - the role of the small heat shock protein, Hsp27, and Akt in protecting cells from heat stress and nerve growth factor withdrawal  Academic Article
• Structural and Functional Studies of thePseudomonas aeruginosaMinor Pilin, PilE  Academic Article
• Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles  Academic Article
• Structure of an Asymmetric Ternary Protein Complex Provides Insight for Membrane Interaction  Academic Article
• Sustained remissions of immune thrombocytopenia associated with the use of thrombopoietin receptor agonists  Academic Article
• Switching to extended half-life products in Canada - preliminary data  Academic Article
• Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf  Academic Article
• T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice  Academic Article
• TNF-alpha reduces cerebral blood volume and disrupts tissue homeostasis via an endothelin- and TNFR2-dependent pathway  Academic Article
• Targeting of passenger protein domains to multiple intracellular membranes  Academic Article
• The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing  Academic Article
• The Orphan Nuclear Hormone Receptor LXR Interacts with the Peroxisome Proliferator-activated Receptor and Inhibits Peroxisome Proliferator Signaling  Academic Article
• The PEA3 Ets Transcription Factor Comprises Multiple Domains That Regulate Transactivation and DNA Binding  Academic Article
• The Transactivation Function of the Pea3 Subfamily Ets Transcription Factors Is Regulated by Sumoylation  Academic Article
• The Transferable Tail:  Fusion of the N-Terminal Acidic Extension of Heparin Cofactor II to α1-Proteinase Inhibitor M358R Specifically Increases the Rate of Thrombin Inhibition†  Academic Article
• The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand  Academic Article
• The inhibition of endocytosis affects HDL-lipid uptake mediated by the human scavenger receptor class B type I  Academic Article
• The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor α-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal β-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase  Academic Article
• Three-Dimensional Spatial Patterning of Proteins in Hydrogels  Academic Article
• Thrombopoietin Receptor Agonists in Primary Immune Thrombocytopenia  Academic Article
• Thrombopoietin-Receptor Agonists for Primary Immune Thrombocytopenia  Academic Article
• Transcriptional regulation of sdiA by cAMP-receptor protein, LeuO, and environmental signals in Salmonella enterica serovar Typhimurium  Academic Article
• Transgenic mice over-expressing substance P exhibit allodynia and hyperalgesia which are reversed by substance P and N-methyl-d-aspartate receptor antagonists  Academic Article
• Tumor Protection Following Vaccination With Low Doses of Lentivirally Transduced DCs Expressing the Self-antigen erbB2  Academic Article
• Tumor-targeting domains for chimeric antigen receptor T cells  Academic Article
• UV-enhanced reactivation of a UV-damaged reporter gene suggests transcription-coupled repair is UV-inducible in human cells  Academic Article
• Undercarboxylation of recombinant prothrombin revealed by analysis of γ-carboxyglutamic acid using capillary electrophoresis and laser-induced fluorescence  Academic Article
• Vector-Derived Expression of Recombinant Rat Interleukin-6  Academic Article
• Viral Engineering of Chimeric Antigen Receptor Expression on Murine and Human T Lymphocytes  Academic Article
• Visual detection method for identifying recombinant bacterial colonies.  Academic Article
• p53 - The Link between Inflammation and Cancer?  Academic Article