Journal article
BCL11A represses HBG transcription in K562 cells
Abstract
BCL11A on chromosome 2p16 was recently shown to be a major quantitative trait locus for Hb F level and F-cell number in several populations with or without beta-hemoglobinopathy. We now show that BCL11A isoforms are expressed in K562 cells. Butyrate induction of HBG globin production in K562 is associated with reduced BCL11A. Conversely, augmented expression of BCL11A in K562 cells through transfection of BCL11A expression vector results in …
Authors
Chen Z; Luo H-Y; Steinberg MH; Chui DHK
Journal
Blood Cells Molecules and Diseases, Vol. 42, No. 2, pp. 144–149
Publisher
Elsevier
Publication Date
March 2009
DOI
10.1016/j.bcmd.2008.12.003
ISSN
1079-9796