Monovalent Fc receptor blockade by an anti–Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity Journal Articles

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abstract

Key Points We generated a novel monovalent anti-FcγRIII/albumin fusion protein that ameliorates antibody-mediated murine ITP. Severe adverse events by anti-FcγR antibodies because of FcγR cross-linking are overcome by monovalent FcγR blockade.

authors

Yu, Xiaojie
Menard, Melissa
Prechl, József
Bhakta, Varsha
Sheffield, William
Lazarus, Alan H

status

published

publication date

January 7, 2016

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Albumins (MeSH)
Animals (MeSH)
Antibodies, Monoclonal (MeSH)
Antibody-Dependent Cell Cytotoxicity (MeSH)
Cells, Cultured (MeSH)
Female (MeSH)
Humans (MeSH)
Immunoglobulin Fc Fragments (MeSH)
Immunology (Science Metrix)
Macrophages (MeSH)
Mice (MeSH)
Purpura, Thrombocytopenic, Idiopathic (MeSH)
Receptors, IgG (MeSH)
Recombinant Fusion Proteins (MeSH)

published in

Blood Journal