Induction of an Immune Response to Transmissible Gastroenteritis Coronavirus Using Vectors with Enteric Tropism

Transmissible gastroenteritis virus (TGEV) causes high mortality in neonatal pigs 1. TGEV has four structural proteins: the spike (S), the nucleoprotein (N), the membrane protein (M), and the small membrane (SM) protein. Protein S is the major inducer of TGEV neutralizing antibodies. Four antigenic sites (A, B, C, and D) have been defined in S protein2, 3, 4. These sites have been located in the amino-end half of S protein. The precise amino …