Journal article
TNF‐α reduces cerebral blood volume and disrupts tissue homeostasis via an endothelin‐ and TNFR2‐dependent pathway
Abstract
TNF-alpha expression is elevated in a variety of neuropathologies, including multiple sclerosis, cerebral malaria and HIV encephalitis. However, the consequences of such high cerebral TNF-alpha expression remain unresolved. Here, using MRI, we demonstrate that a focal intrastriatal injection of TNF-alpha causes a significant, acute reduction (15-30%) in cerebral blood volume (CBV), which is dependent on TNF-alpha-type 2 receptor (TNFR2) …
Authors
Sibson NR; Blamire AM; Perry VH; Gauldie J; Styles P; Anthony DC
Journal
Brain, Vol. 125, No. 11, pp. 2446–2459
Publisher
Oxford University Press (OUP)
Publication Date
November 1, 2002
DOI
10.1093/brain/awf256
ISSN
0006-8950
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AnimalsAntigens, CDBlood-Brain BarrierBrainCentral Nervous System DiseasesCerebrospinal FluidCerebrovascular CirculationDrug Administration ScheduleEndothelinsEnergy MetabolismHomeostasisMagnetic Resonance ImagingMaleNeostriatumRatsRats, WistarReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type IIRecombinant Fusion ProteinsSignal TransductionTumor Necrosis Factor-alphaWater-Electrolyte Balance