Journal article
Characterization of a long-acting recombinant human serum albumin-atrial natriuretic factor (ANF) expressed in Pichia pastoris
Abstract
The cardiac hormone atrial natriuretic factor (ANF) combines pharmacological properties of drugs used to treat essential hypertension (EH), congestive heart failure (CHF) and acute myocardial infarction (AMI). Treatment of CHF or AMI patients with an intravenous (iv) infusion of the circulating form of ANF (ANF(99-126)) produces significant clinical improvement. The short half-life (5 min) and peptide nature of ANF impose logistic restrictions …
Authors
de Bold MK; Sheffield WP; Martinuk A; Bhakta V; Eltringham-Smith L; de Bold AJ
Journal
Peptides, Vol. 175, No. 1-3, pp. 7–10
Publisher
Elsevier
Publication Date
April 2012
DOI
10.1016/j.regpep.2012.01.005
ISSN
0196-9781