Viral Engineering of Chimeric Antigen Receptor Expression on Murine and Human T Lymphocytes Academic Article uri icon

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abstract

  • The adoptive transfer of a bolus of tumor-specific T lymphocytes into cancer patients is a promising therapeutic strategy. In one approach, tumor specificity is conferred upon T cells via engineering expression of exogenous receptors, such as chimeric antigen receptors (CARs). Here, we describe the generation and production of both murine and human CAR-engineered T lymphocytes using retroviruses.

publication date

  • 2016