Journal article
Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells
Abstract
Delta-mediated Notch signaling controls cell fate decisions during invertebrate and murine development. However, in the human, functional roles for Delta have yet to be described. This study reports the characterization of Delta-1 and Delta-4 in the human. Human Delta-4 was found to be expressed in a wide range of adult and fetal tissues, including sites of hematopoiesis. Subsets of immature hematopoietic cells, along with stromal and …
Authors
Karanu FN; Murdoch B; Miyabayashi T; Ohno M; Koremoto M; Gallacher L; Wu D; Itoh A; Sakano S; Bhatia M
Journal
Blood, Vol. 97, No. 7, pp. 1960–1967
Publisher
American Society of Hematology
Publication Date
April 1, 2001
DOI
10.1182/blood.v97.7.1960
ISSN
0006-4971
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptor Proteins, Signal TransducingAdultAmino Acid SequenceAnimalsBlood ProteinsCalcium-Binding ProteinsCell DifferentiationCell DivisionCells, CulturedFetal BloodGene Expression Regulation, DevelopmentalGraft SurvivalGrowth SubstancesHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHumansInfant, NewbornIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, Inbred NODMice, SCIDMitosisMolecular Sequence DataReceptor, Notch1Receptor, Notch2Receptors, Cell SurfaceRecombinant Fusion ProteinsSequence AlignmentSequence Homology, Amino AcidSevere Combined ImmunodeficiencySignal TransductionSolubilityTranscription FactorsTransplantation, Heterologous