Journal article
Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches.
Abstract
The elbow (elB) gene encodes a conserved nuclear protein with a single zinc finger. Expression of ElB is restricted to a specific subset of tracheal cells, namely the dorsal branch and the lateral trunks. Stalled or aberrant migration of these branches is observed in elB mutant embryos. Conversely, ElB misexpression in the trachea gave rise to absence of the visceral branch and an increase in the number of cells forming the dorsal branch. These …
Authors
Dorfman R; Glazer L; Weihe U; Wernet MF; Shilo B-Z
Journal
Development, Vol. 129, No. 15, pp. 3585–3596
Publisher
The Company of Biologists
Publication Date
August 1, 2002
DOI
10.1242/dev.129.15.3585
ISSN
0950-1991
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceAnimalsBasic Helix-Loop-Helix Transcription FactorsCarrier ProteinsCell MovementDNA-Binding ProteinsDrosophila ProteinsDrosophila melanogasterEmbryonic DevelopmentHumansIn Situ HybridizationMolecular Sequence DataMorphogenesisNuclear ProteinsPhenotypeRecombinant Fusion ProteinsRepressor ProteinsSequence AlignmentTracheaTranscription FactorsZinc Fingers