Journal article
Insulin acutely decreases hepatic fatty acid synthase activity
Abstract
Insulin is viewed as a positive regulator of fatty acid synthesis by increasing fatty acid synthase (FAS) mRNA transcription. We uncover a new mechanism by which insulin acutely reduces hepatic FAS activity by inducing phosphorylation of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and its interaction with FAS. Ceacam1 null mice (Cc1(-/-)) show loss of insulin's ability to acutely decrease hepatic FAS activity. …
Authors
Najjar SM; Yang Y; Fernström MA; Lee S-J; DeAngelis AM; Rjaily GAA; Al-Share QY; Dai T; Miller TA; Ratnam S
Journal
Cell Metabolism, Vol. 2, No. 1, pp. 43–53
Publisher
Elsevier
Publication Date
7 2005
DOI
10.1016/j.cmet.2005.06.001
ISSN
1550-4131