Journal article
Hypophosphatasia: Canadian update on diagnosis and management
Abstract
Hypophosphatasia (HPP) is a rare inherited disorder of bone and mineral metabolism caused by loss of function mutations in the ALPL gene. The presentation in children and adults can be extremely variable and natural history is poorly understood particularly in adults. Careful patient evaluation is required with consideration of pharmacologic intervention in individuals meeting criteria for therapy.IntroductionThe purposes of this review are to …
Authors
Khan AA; Josse R; Kannu P; Villeneuve J; Paul T; Van Uum S; Greenberg CR
Journal
Osteoporosis International, Vol. 30, No. 9, pp. 1713–1722
Publisher
Springer Nature
Publication Date
September 2019
DOI
10.1007/s00198-019-04921-y
ISSN
0937-941X