Journal article
Characterization of the mouse lysosomal sialidase promoter
Abstract
Lysosomal sialidase is required for the catabolism of sialoglycoconjugates such as gangliosides and deficiency in this enzyme results in the autosomal recessive disease sialidosis. Furthermore, we have shown that overexpression of human sialidase is sufficient to clear accumulated ganglioside in Tay-Sachs neuroglia [Hum. Mol. Genet. 8 (1999) 1111]. In this paper, we have characterized the 5' regulatory region of the mouse lysosomal sialidase …
Authors
Champigny MJ; Johnson M; Igdoura SA
Journal
Gene, Vol. 319, , pp. 177–187
Publisher
Elsevier
Publication Date
November 2003
DOI
10.1016/s0378-1119(03)00808-4
ISSN
0378-1119
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
5' Flanking RegionAnimalsBase SequenceBinding SitesCCAAT-Enhancer-Binding ProteinsCell LineCell Line, TumorConserved SequenceDNA FootprintingDNA-Binding ProteinsElectrophoretic Mobility Shift AssayEvolution, MolecularHepatocyte Nuclear Factor 1Hepatocyte Nuclear Factor 1-alphaHepatocyte Nuclear Factor 1-betaHomeodomain ProteinsHumansLuciferasesLysosomesMiceMice, Inbred C57BLMolecular Sequence DataMyoD ProteinNIH 3T3 CellsNeuraminidaseNuclear ProteinsPromoter Regions, GeneticProtein BindingRatsRecombinant Fusion ProteinsRegulatory Sequences, Nucleic AcidRepressor ProteinsSequence Homology, Nucleic AcidSp1 Transcription FactorTranscription Factors