Journal article
Lengthened G1 Phase Indicates Differentiation Status in Human Embryonic Stem Cells
Abstract
The cell cycle in pluripotent stem cells is notable for the brevity of the G1 phase, permitting rapid proliferation and reducing the duration of differentiation signal sensitivity associated with the G1 phase. Changes in the length of G1 phase are understood to accompany the differentiation of human embryonic stem cells (hESCs), but the timing and extent of such changes are poorly defined. Understanding the early steps governing the …
Authors
Calder A; Roth-Albin I; Bhatia S; Pilquil C; Lee JH; Bhatia M; Levadoux-Martin M; McNicol J; Russell J; Collins T
Journal
Stem Cells and Development, Vol. 22, No. 2, pp. 279–295
Publisher
Mary Ann Liebert
Publication Date
January 15, 2013
DOI
10.1089/scd.2012.0168
ISSN
1547-3287
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Antigens, DifferentiationBiomarkersCell DifferentiationCell LineCell MovementCell ProliferationCulture MediaEmbryonic Stem CellsFluorescent Antibody Technique, IndirectG1 PhaseGATA4 Transcription FactorGenes, ReporterGreen Fluorescent ProteinsHumansPhenotypePluripotent Stem CellsRecombinant Fusion ProteinsTime FactorsTime-Lapse ImagingTransgenes