Journal article
Interaction of Cyclin-dependent Kinase 5 (Cdk5) and Neuronal Cdk5 Activator in Bovine Brain (∗)
Abstract
Neuronal cdc2-like kinase (Nclk) purified from bovine brain is a heterodimer of Cdk5 and an essential 25-kDa regulatory subunit (Lew, J., and Wang, J. H. (1995) Trends Biochem. Sci. 20, 33-37). The regulatory subunit is an N-terminal truncated derivative of a 35-kDa protein expressed specifically in brain, hence the name neuronal Cdk5 activator, p25/p35nck5a. In this study, we probe the relationship between the two different forms of Nck5a and …
Authors
Lee K-Y; Rosales JL; Tang D; Wang JH
Journal
Journal of Biological Chemistry, Vol. 271, No. 3, pp. 1538–1543
Publisher
Elsevier
Publication Date
January 1996
DOI
10.1074/jbc.271.3.1538
ISSN
0021-9258
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBrainCattleChromatography, GelChromatography, Ion ExchangeCloning, MolecularCyclin-Dependent Kinase 5Cyclin-Dependent KinasesElectrophoresis, Polyacrylamide GelEthylene GlycolEthylene GlycolsMacromolecular SubstancesNerve Tissue ProteinsNeuronsProtamine KinaseProtein Serine-Threonine KinasesRecombinant Fusion Proteins