Ligands Concept

subject area of

• N,N-Bis(2-mercaptoethyl)methylamine:  A New Coligand for Tc-99m Labeling of Hydrazinonicotinamide Peptides  Journal Articles
• A Comparison of Toll-Like Receptor 5 and 21 Ligands as Adjuvants for a Formaldehyde Inactivated H9N2 Avian Influenza Virus Vaccine in Chickens  Journal Articles
• A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease  Journal Articles
• A New Strategy for the Preparation of Peptide-Targeted Technetium and Rhenium Radiopharmaceuticals. The Automated Solid-Phase Synthesis, Characterization, Labeling, and Screening of a Peptide-Ligand Library Targeted at the Formyl Peptide Receptor  Journal Articles
• A PPARγ mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus  Journal Articles
• A Solid-Phase Labeling Strategy for the Preparation of Technetium and Rhenium Bifunctional Chelate Complexes and Associated Peptide Conjugates  Journal Articles
• A critical role for IL‐15 in TLR‐mediated innate antiviral immunity against genital HSV‐2 infection  Journal Articles
• A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin  Journal Articles
• A ligand of the p65/p95 receptor suppresses perforant path kindling, kindling-induced mossy fiber sprouting, and hilar area changes in adult rats  Journal Articles
• A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function  Journal Articles
• A p56 Ligand Serves as a Coactivator of an Orphan Nuclear Hormone Receptor  Journal Articles
• A robust strategy for the preparation of libraries of metallopeptides. A new paradigm for the discovery of targeted molecular imaging and therapy agents  Journal Articles
• Access and Binding of Local Anesthetics in the Closed Sodium Channel  Journal Articles
• Accumulation of ligands for aryl hydrocarbon and sex steroid receptors in fish exposed to treated effluent from a bleached sulfite/groundwood pulp and paper mill  Journal Articles
• Allosteric Mechanisms of Nonadditive Substituent Contributions to Protein-Ligand Binding  Journal Articles
• Alloxan inhibits ligand binding to adrenoceptors of vascular smooth muscle microsomes  Journal Articles
• Analyses of cellular multimerin 1 receptors: in vitro evidence of binding mediated by αΙΙbβ3 and αvβ3  Journal Articles
• Analysis of the pi-pi stacking interactions between the aminoglycoside antibiotic kinase APH(3')-IIIa and its nucleotide ligands  Journal Articles
• Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation  Journal Articles
• Assessing wild fish exposure to ligands for sex steroid receptors from pulp and paper mill effluents in the Biobio River Basin, Central Chile  Journal Articles
• Bio-Solid-Phase Extraction/Tandem Mass Spectrometry for Identification of Bioactive Compounds in Mixtures  Journal Articles
• Bridging the Gap between in Vitro and in Vivo Imaging:  Isostructural Re and^99mTc Complexes for Correlating Fluorescence and Radioimaging Studies  Journal Articles
• Ca²⁺ channel ligand activities in uterine smooth muscle: influence of hormonal status  Journal Articles
• Carbamoylphosphate requirement for synthesis of the active center of [NiFe]‐hydrogenases  Journal Articles
• Cellular binding and/or uptake of nickel(II) ions.  Journal Articles
• Characterization of a Novel Primary Mammary Tumor Cell Line Reveals that Cyclin D1 Is Regulated by the Type I Insulin-Like Growth Factor Receptor  Journal Articles
• Chemical modification reveals involvement of tyrosine in ligand binding to dopamine D1 and D2 receptors.  Journal Articles
• Clorgyline-induced switch from locomotion to mouthing in sensitization to the dopamine D2/D3 agonist quinpirole in rats: role of sigma and imidazoline I2 receptors  Journal Articles
• Cognitive impairments of alcoholic cirrhotic patients: correlation with endogenous benzodiazepine receptor ligands and increased affinity of platelet receptors.  Journal Articles
• Comparison of lowest energy conformations of dimethylcurine and methoxyverapamil: Evidence of ternary association of calcium channel, Ca2+, and calcium entry blockers  Journal Articles
• Computational Analysis of the Crystal and Cryo-EM Structures of P-Loop Channels with Drugs  Journal Articles
• Computational Structural Pharmacology and Toxicology of Voltage-Gated Sodium Channels  Chapters
• Conformational Analysis of the Ca²⁺-Bound Opioid Peptides: Implications for Ligand-Receptor Interaction  Journal Articles
• Conformational and Electrostatic Similarity Between Polyprotonated and Ca²⁺-Boundμ-Opioid Peptides  Journal Articles
• Conformational states of aspartate transcarbamoylase stabilized with a cross-linking reagent.  Journal Articles
• Constituents within pulp mill effluent deplete retinoid stores in white sucker and bind to rainbow trout retinoic acid receptors and retinoid × receptors  Journal Articles
• Controlling Gene Expression in Living Cells Through Small Molecule-RNA Interactions  Journal Articles
• Cross-chimeric analysis of selectivity of secretin and VPAC(1) receptor activation.  Journal Articles
• Cutting Edge: FimH Adhesin of Type 1 Fimbriae Is a Novel TLR4 Ligand  Journal Articles
• Design and Synthesis of Photoaffinity-Labeling Ligands of thel-Prolyl-l-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor  Journal Articles
• Design and synthesis of site directed maleimide bifunctional chelators for technetium and rhenium  Journal Articles
• Determination of Strong Ligand Sites in Sewage Effluent-Impacted Waters by Competitive Ligand Titration with Silver  Journal Articles
• Development of Better Aptamers: Structured Library Approaches, Selection Methods, and Chemical Modifications  Journal Articles
• Different binding sites for the neuropeptide Y Y1 antagonists 1229U91 and J-104870 on human Y1 receptors  Journal Articles
• Differential inhibitory effects of melatonin analogs and three naphthalenic ligands on 2‐[¹²⁵I]iodomelatonin binding to chicken tissues  Journal Articles
• Differential response of primitive human CD34− and CD34+ hematopoietic cells to the Notch ligand Jagged-1  Journal Articles
• Docking flexible ligands in proteins with a solvent exposure- and distance-dependent dielectric function  Journal Articles
• Dopamine D2 receptors quantified in vivo in human narcolepsy  Journal Articles
• Dynamic unfolding of a regulatory subunit of cAMP‐dependent protein kinase by capillary electrophoresis: Impact of cAMP dissociation on protein stability  Journal Articles
• Dynamically Driven Ligand Selectivity in Cyclic Nucleotide Binding Domains  Journal Articles
• Effect of copper on ion content in isolated mantle cells of the marine clam Mesodesma mactroides  Journal Articles
• Evaluation of DNA aptamers directed to thrombin as potential thrombus imaging agents  Journal Articles
• Evaluation of the effect of reactive sulfide on the acute toxicity of silver (I) to Daphnia magna. Part 1: Description of the chemical system  Journal Articles
• Evaluation of the effect of reactive sulfide on the acute toxicity of silver (I) to Daphnia magna. Part 2: Toxicity results  Journal Articles
• Evidence That Both Exosites on Thrombin Participate in Its High Affinity Interaction with Fibrin  Journal Articles
• Evidence for Allosteric Linkage between Exosites 1 and 2 of Thrombin  Journal Articles
• Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels  Journal Articles
• Evidence of Kinetic Control of Ligand Binding and Staged Product Release in MurA (Enolpyruvyl UDP-GlcNAc Synthase)-Catalyzed Reactions,  Journal Articles
• Exosite 2-Directed Ligands Attenuate Protein C Activation by the Thrombin–Thrombomodulin Complex  Journal Articles
• Extension of the Single Amino Acid Chelate Concept (SAAC) to Bifunctional Biotin Analogues for Complexation of the M(CO)₃⁺¹ Core (M = Tc and Re):  Syntheses, Characterization, Biotinidase Stability, and Avidin Binding  Journal Articles
• FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis  Journal Articles
• Fluorous ligand capture (FLC): a chemoselective solution-phase strategy for isolating 99mTc-labelled compounds in high effective specific activity  Journal Articles
• From Bench to Bedside  Journal Articles
• Functional Screening of Pharmacological Chaperones via Restoration of Enzyme Activity upon Denaturation  Journal Articles
• Functional characterization of estrogen receptor subtypes, ERα and ERβ, mediating vitellogenin production in the liver of rainbow trout  Journal Articles
• General occurrence of binding synergism in zinc proteases and its possible significance  Journal Articles
• Glucose‐regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders  Journal Articles
• HD1, a Thrombin-directed Aptamer, Binds Exosite 1 on Prothrombin with High Affinity and Inhibits Its Activation by Prothrombinase  Journal Articles
• High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells  Journal Articles
• High-throughput screening of holoprotein conformational stability by dynamic ligand exchange-affinity capillary electrophoresis  Journal Articles
• Histidine-rich Glycoprotein Binds Fibrin(ogen) with High Affinity and Competes with Thrombin for Binding to the γ′-Chain  Journal Articles
• Homology Model of Dihydropyridine Receptor: Implications for L-type Ca2+ Channel Modulation by Agonists and Antagonists  Journal Articles
• Homology Models of μ-Opioid Receptor with Organic and Inorganic Cations at Conserved Aspartates in the Second and Third Transmembrane Domains  Journal Articles
• HypF, a Carbamoyl Phosphate-converting Enzyme Involved in [NiFe] Hydrogenase Maturation  Journal Articles
• IL-15 and Type I Interferon Are Required for Activation of Tumoricidal NK Cells by Virus-Infected Dendritic Cells  Journal Articles
• Identification of Small Molecules that Sensitize Resistant Tumor Cells to Tumor Necrosis Factor-Family Death Receptors  Journal Articles
• Identification of novel catecholamine absorbing proteins in the central nervous system  Journal Articles
• Immunohistochemical and functional studies on calcium‐sensing receptors in rat uterine smooth muscle  Journal Articles
• Implementation of the NMR CHEmical Shift Covariance Analysis (CHESCA): A Chemical Biologist’s Approach to Allostery  Books
• Induction of Innate Immunity against Herpes Simplex Virus Type 2 Infection via Local Delivery of Toll-Like Receptor Ligands Correlates with Beta Interferon Production  Journal Articles
• Induction of hTERT Expression and Telomerase Activity by Estrogens in Human Ovary Epithelium Cells  Journal Articles
• Insulin resistance corresponds with a progressive increase in NOD1 in high fat diet-fed mice  Journal Articles
• Integrins Regulate Responsiveness to Slit Repellent Signals  Journal Articles
• Interaction of d-Tubocurarine with Potassium Channels: Molecular Modeling and Ligand Binding  Journal Articles
• Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction  Journal Articles
• Interactions of drugs and toxins with permeant ions in potassium, sodium, and calcium channels.  Journal Articles
• KDBI: Kinetic Data of Bio-molecular Interactions database  Journal Articles
• Kappa-opioid receptor stimulation quickens pathogenesis of compulsive checking in the quinpirole sensitization model of obsessive-compulsive disorder (OCD).  Journal Articles
• Kinked-Helices Model of the Nicotinic Acetylcholine Receptor Ion Channel and Its Complexes with Blockers: Simulation by the Monte Carlo Minimization Method  Journal Articles
• KvAP-Based Model of the Pore Region of Shaker Potassium Channel Is Consistent with Cadmium- and Ligand-Binding Experiments  Journal Articles
• Label-Free Assay for Thermodynamic Analysis of Protein−Ligand Interactions: A Multivariate Strategy for Allosteric Ligand Screening  Journal Articles
• Lack of Association Between Thiazolidinediones and Macular Edema in Type 2 Diabetes  Journal Articles
• Leukemia targeting ligands isolated from phage display peptide libraries  Journal Articles
• Ligand action on sodium, potassium, and calcium channels: role of permeant ions  Journal Articles
• Ligand interactions at the active site of aspartate transcarbamoylase from Escherichia coli  Journal Articles
• Ligand-dependent interactions between SR-B1 and S1PR1 in macrophages and atherosclerotic plaques  Journal Articles
• Ligands of Diltiazem Binding Site: An Overview of Some Chemotypes  Journal Articles
• Lipid binding protein response to a bile acid library: a combined NMR and statistical approach  Journal Articles
• Liposomal delivery of gene therapy for ovarian cancer: a systematic review  Journal Articles
• Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative  Journal Articles
• Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis  Journal Articles
• MDMA-evoked changes in the binding of dopamine D₂receptor ligands in striatum of rats with unilateral serotonin depletion  Journal Articles
• Mapping Allostery through Equilibrium Perturbation NMR Spectroscopy  Journal Articles
• Mapping of Steroids Binding to 17β-Hydroxysteroid Dehydrogenase Type 1 Using Monte Carlo Energy Minimization Reveals Alternative Binding Modes  Journal Articles
• Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist  Journal Articles
• Mechanism of acute silver toxicity in Daphnia magna  Journal Articles
• Metal insertion into NiFe-hydrogenases  Journal Articles
• Metal sulfides in oxygenated aquatic systems: implications for the biotic ligand model  Journal Articles
• Modeling P-Loops Domain of Sodium Channel: Homology with Potassium Channels and Interaction with Ligands  Journal Articles
• Modeling interactions between blocking and permeant cations in the NavMs channel  Journal Articles
• Molecular Modeling of Benzothiazepine Binding in the L-type Calcium Channel  Journal Articles
• Monte Carlo-energy minimization of correolide in the Kv1.3 channel: possible role of potassium ion in ligand-receptor interactions.  Journal Articles
• Monte Carlo-minimized energy profile of estradiol in the ligand-binding tunnel of 17?-hydroxysteroid dehydrogenase: Atomic mechanisms of steroid recognition  Journal Articles
• Mutual Protein-Ligand Conformational Selection Drives cGMP vs. cAMP Selectivity in Protein Kinase G  Journal Articles
• Neurotrophin-4/5 Alters Responses and Blocks the Effect of Monocular Deprivation in Cat Visual Cortex during the Critical Period  Journal Articles
• Non-sterol structural probes of the lanosterol 14α-demethylase from Saccharomyces cerevisiae  Journal Articles
• Noxious stimulation decreases substance P binding in rat spinal dorsal horn  Journal Articles
• Oncostatin M and TLR-4 Ligand Synergize to Induce MCP-1, IL-6, and VEGF in Human Aortic Adventitial Fibroblasts and Smooth Muscle Cells  Journal Articles
• Oncostatin M overexpression induces matrix deposition, STAT3 activation, and SMAD1 Dysregulation in lungs of fibrosis-resistant BALB/c mice  Journal Articles
• Opioid receptors in human neuroblastoma SH-SY5Y cells: Evidence for distinct morphine (μ) and enkephalin (δ) binding sites  Journal Articles
• Optimization of plasma-based BioID identifies plasminogen as a ligand of ADAMTS13  Journal Articles
• Oxysterol Activators of Liver X Receptor and 9-cis-Retinoic Acid Promote Sequential Steps in the Synthesis and Secretion of Tumor Necrosis Factor-α from Human Monocytes  Journal Articles
• PPAR ligands decrease human airway smooth muscle cell migration and extracellular matrix synthesis  Journal Articles
• Peroxisome Proliferator-activated Receptor γ Ligands Differentially Modulate Muscle Cell Differentiation and MyoD Gene Expression via Peroxisome Proliferator-activated Receptor γ-dependent and -independent Pathways  Journal Articles
• Phenylalkylamines in calcium channels: computational analysis of experimental structures  Journal Articles
• Polymorphism in the Innate Immune Receptor SIRPα Controls CD47 Binding and Autoimmunity in the Nonobese Diabetic Mouse  Journal Articles
• Potassium Channel Block by a Tripartite Complex of Two Cationophilic Ligands and a Potassium Ion  Journal Articles
• Potassium, sodium, calcium and glutamate‐gated channels: pore architecture and ligand action  Journal Articles
• Preparation and Evaluation of Radiolabeled Antibody Recruiting Small Molecules That Target Prostate-Specific Membrane Antigen for Combined Radiotherapy and Immunotherapy  Journal Articles
• Probing ligand selectivity in pathogens  Journal Articles
• Protein expression changes in the Sprague Dawley rat liver proteome following administration of peroxisome proliferator activated receptor α and γ ligands  Journal Articles
• Pseudomonas aeruginosa FpvB Is a High-Affinity Transporter for Xenosiderophores Ferrichrome and Ferrioxamine B  Journal Articles
• Quantification of the Soluble Leptin Receptor in Human Blood by Ligand-Mediated Immunofunctional Assay  Conferences
• Quantitative autoradiography of ligands for dopamine receptors and transporters in brain of Göttingen minipig: Comparison with results in vivo  Journal Articles
• Quantum Mechanics/Molecular Mechanics Strategies for Docking Pose Refinement: Distinguishing between Binders and Decoys in CytochromecPeroxidase  Journal Articles
• REVIEW ARTICLE: The Role of Toll‐Like Receptor Ligands/Agonists in Protection Against Genital HSV‐2 Infection  Journal Articles
• Receptor domains of two-component signal transduction systems  Journal Articles
• Receptors for non-MHC ligands contribute to uterine natural killer cell activation during pregnancy in mice  Journal Articles
• Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs  Journal Articles
• Regulation of profibrotic responses by ADAM17 activation in high glucose requires its C-terminus and FAK  Journal Articles
• Robustness of the BMP morphogen gradient in Drosophila embryonic patterning  Journal Articles
• Role of Half-of-Sites Reactivity and Inter-Subunit Communications in DAHP Synthase Catalysis and Regulation  Journal Articles
• Role of metal ions in ligand–receptor interaction: Insights from structural studies  Journal Articles
• SOCS3 inhibits the mesenchymal stromal cell secretory factor SDF-1-mediated improvement of islet function in non-obese diabetic mice  Journal Articles
• Screening of ligands for redox-active europium using magnetic resonance imaging  Journal Articles
• Signal Transduction within G-protein Coupled Receptors via an Ion Tunnel: A Hypothesis  Journal Articles
• Sodium channel activators: Model of binding inside the pore and a possible mechanism of action  Journal Articles
• Structural Model for Dihydropyridine Binding to L-type Calcium Channels  Journal Articles
• Structural Models of Ligand-Bound Sodium Channels  Journal Articles
• Structural model of a synthetic Ca2+ channel with bound Ca2+ ions and dihydropyridine ligand  Journal Articles
• Studies of Melatonin Effects on Epithelia Using the Human Embryonic Kidney-293 (HEK-293) Cell Line*  Journal Articles
• Subunit interactions in aspartate transcarbamylase. A model for the allosteric mechanism  Journal Articles
• Subunit interactions in aspartate transcarbamylase. The interaction between catalytic and regulatory subunits and the effect of ligands  Journal Articles
• Surface Immobilization of Structure-Switching DNA Aptamers on Macroporous Sol−Gel-Derived Films for Solid-Phase Biosensing Applications  Journal Articles
• Surface Phenotype and Functionality of WNV Specific T Cells Differ with Age and Disease Severity  Journal Articles
• Sweet Taste in Man: A Review  Journal Articles
• Synergistic binding of hydrophobic probes and zinc ligands to thermolysin  Journal Articles
• Synergistic binding of ligands to angiotensin-converting enzyme.  Journal Articles
• Synthesis and Evaluation of Radioiodinated Acyloxymethyl Ketones as Activity-Based Probes for Cathepsin B  Journal Articles
• Synthesis and Screening of Mono- and Di-Aryl Technetium and Rhenium Metallocarboranes. A New Class of Probes for the Estrogen Receptor  Journal Articles
• Synthesis and Screening of a Library of Re/Tc-Based Amyloid Probes Derived from β-Breaker Peptides  Journal Articles
• Synthesis, Characterisation, and Biodistribution of Radioiodinated C‐Hydroxy‐Carboranes  Journal Articles
• Synthesis, NMR, and X-ray Crystallographic Analysis of C-Hydrazino-C-Carboxycarboranes:  Versatile Ligands for the Preparation of BNCT and BNCS Agents and ^99mTc Radiopharmaceuticals  Journal Articles
• Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands  Journal Articles
• T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice  Journal Articles
• T cell‐mediated induction of thymic stromal lymphopoietin in differentiated human primary bronchial epithelial cells  Journal Articles
• Taming of a Poison: Biosynthesis of the NiFe-Hydrogenase Cyanide Ligands  Journal Articles
• Targeting macrophage scavenger receptor 1 promotes insulin resistance in obese male mice  Journal Articles
• Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis  Journal Articles
• The Effects of Extracellular Calcium-Sensing Receptor Ligands on the Contractility of Pregnant Human Myometrium In Vitro  Journal Articles
• The FMS-like tyrosine kinase-3 ligand/lung dendritic cell axis contributes to regulation of pulmonary fibrosis  Journal Articles
• The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells  Journal Articles
• The direct effects of Toll-like receptor ligands on human NK cell cytokine production and cytotoxicity  Journal Articles
• The effects of pulp mill effluent on the sex steroid binding protein in white sucker (Catostomus commersoni) and longnose sucker (C. catostomus)  Journal Articles
• The platelet cytoskeleton stabilizes the interaction between αIIbβ3 and its ligand and induces selective movements of ligand-occupied integrin  Other
• Toll‐Like Receptor (TLR)–3, but Not TLR4, Agonist Protects against Genital Herpes Infection in the Absence of Inflammation Seen with CpG DNA  Journal Articles
• Treatment of Non-Obese Diabetic (NOD)/Severe-Combined Immunodeficient Mice (SCID) With flt3 Ligand and Interleukin-7 Impairs the B-Lineage Commitment of Repopulating Cells After Transplantation of Human Hematopoietic Cells  Journal Articles
• Using a Riboswitch Sensor to Examine Coenzyme B12 Metabolism and Transport in E. coli  Journal Articles
• Utility of in vitro test methods to assess the activity of xenoestrogens in fish  Journal Articles
• Vimentin Exposed on Activated Platelets and Platelet Microparticles Localizes Vitronectin and Plasminogen Activator Inhibitor Complexes on Their Surface  Journal Articles
• [Molecular physiology of adrenoreceptors].  Journal Articles
• [Productive conformations of ligands and topography of the alpha1-adrenoreceptor active site based on theoretical conformation analysis].  Journal Articles
• [Topography of the active site of the noradrenaline neuronal membrane carrier based on the theoretical conformation analysis of inhibitors of neuronal catecholamine uptake].  Journal Articles
• {Re^IIICl₃} Core Complexes with Bifunctional Single Amino Acid Chelates  Journal Articles