Kappa-Opioid Receptor Stimulation Quickens Pathogenesis of Compulsive Checking in the Quinpirole Sensitization Model of Obsessive–Compulsive Disorder (OCD)

Repeated injections of the D2/D3 dopamine agonist, quinpirole, induce locomotor sensitization and compulsive checking behavior in rats, a phenomenon that may constitute an animal model of obsessive- compulsive disorder (OCD). Considering that the co-joint treatment with quinpirole and the kappa opioid receptor agonist U69593 potentiates locomotor sensitization to quinpirole, the present study examined whether such co-stimulation of kappa and …