The platelet cytoskeleton stabilizes the interaction between αIIbβ3 and its ligand and induces selective movements of ligand-occupied integrin Article uri icon

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abstract

  • Download Citation on ResearchGate \textbar The platelet cytoskeleton stabilizes the interaction between αIIbβ3 and its ligand and induces selective movements of ligand-occupied integrin \textbar Previously, we showed that a subpopulation of the major platelet integrin, alphaIIbbeta3, co-sediments from detergent lysates with talin and other membrane skeleton proteins. Once alphaIIbbeta3 has bound adhesive ligand in a platelet aggregate, the detergent-insoluble... \textbar Keywords: Cytoskeleton, Ligand and Integrins

authors

  • Rathbone, Raelene Lorna
  • Fox, Joan EB
  • Shattil, Sanford J
  • Kinlough-Rathbone, Raelene L
  • Richardson, Mary
  • Packham, Marian A
  • Sanan, David A

publication date

  • March 22, 1996