Journal article
The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells
Abstract
The Notch ligand, Jagged-1, plays an essential role in tissue formation during embryonic development of primitive organisms. However, little is known regarding the role of Jagged-1 in the regulation of tissue-specific stem cells or its function in humans. Here, we show that uncommitted human hematopoietic cells and cells that comprise the putative blood stem cell microenvironment express Jagged-1 and the Notch receptors. Addition of a soluble …
Authors
Karanu FN; Murdoch B; Gallacher L; Wu DM; Koremoto M; Sakano S; Bhatia M
Journal
Journal of Experimental Medicine, Vol. 192, No. 9, pp. 1365–1372
Publisher
Rockefeller University Press
Publication Date
November 6, 2000
DOI
10.1084/jem.192.9.1365
ISSN
0022-1007
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntigens, CDBlood Cell CountCalcium-Binding ProteinsCell DivisionCell SurvivalCells, CulturedCytokinesFlow CytometryGene ExpressionGrowth SubstancesHematopoiesisHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHumansIntercellular Signaling Peptides and ProteinsJagged-1 ProteinLigandsMembrane ProteinsMiceMice, Inbred NODMice, SCIDProtein BindingProteinsRNA, MessengerReceptors, NotchSerrate-Jagged Proteins