Journal article
Utility of in vitro test methods to assess the activity of xenoestrogens in fish
Abstract
The results of the present study have demonstrated the utility of an estrogen receptor (ER) competitive ligand-binding assay, a hepatocyte vitellogenin (VTG) induction bioassay, and an ER reporter gene bioassay in characterizing the activity of model estrogen agonists (17beta-estradiol [E2], ethynylestradiol, and nonylphenol) and antagonists (tamoxifen and ZM 189154) in rainbow trout (Oncorhynchus mykiss). The in vitro results were validated …
Authors
Marlatt VL; Hewitt LM; Van Der Kraak G
Journal
Environmental Toxicology and Chemistry, Vol. 25, No. 12, pp. 3204–3212
Publisher
Oxford University Press (OUP)
Publication Date
December 1, 2006
DOI
10.1897/05-686r.1
ISSN
0730-7268