Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands Academic Article uri icon

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abstract

  • The syntheses, structures and biological evaluation of a series of cisplatin-like complexes containing bis(imidazole) derivatives - the so-called Joseph ligands - are described. Their cytotoxicity is discussed in terms of their polar surface area, rate of aquation, and lipophilicity. The X-ray crystal structure of the platinum diiodido derivative of dimethyl 2-(di(1H-imidazol-2-yl)methyl)malonate) is reported and compared to those of related systems. Molecular modeling studies are focused on the hydrogen bonding properties of such systems, and their relevance to antitumor activity.

authors

  • Ravera, Mauro
  • Gabano, Elisabetta
  • Sardi, Manuele
  • Ermondi, Giuseppe
  • Caron, Giulia
  • Mcglinchey, Michael James
  • Müller-Bunz, Helge
  • Monti, Elena
  • Gariboldi, Marzia B
  • Osella, Domenico

publication date

  • March 2011