Probing ligand selectivity in pathogens Journal Articles

abstract

• Why does protein kinase A respond to purine nucleosides in certain pathogens, but not to the cyclic nucleotides that activate this kinase in most other organisms?

authors

• VanSchouwen, Bryan
• Melacini, Giuseppe

publication date

• December 21, 2023

has subject area

• 0601 Biochemistry and Cell Biology (FoR)
• Cyclic AMP-Dependent Protein Kinases (MeSH)
• Leishmania donovani (MeSH)
• Ligands (MeSH)
• Phosphotransferases (MeSH)
• Purine Nucleosides (MeSH)
• Trypanosoma brucei brucei (MeSH)

published in

• eLife  Journal

keywords

• Cyclic AMP-Dependent Protein Kinases
• L. donovani
• Leishmania donovani
• Ligands
• Phosphotransferases
• Protein kinase A
• Purine Nucleosides
• T. brucei
• T. cruzi
• Trypanosoma brucei brucei
• biochemistry
• chemical biology
• infectious disease
• ligand selectivity
• microbiology
• trypanosomatid pathogens

Digital Object Identifier (DOI)

• 10.7554/elife.94720

start page

• e94720

volume

• 12