Journal article
Oxysterol Activators of Liver X Receptor and 9-cis-Retinoic Acid Promote Sequential Steps in the Synthesis and Secretion of Tumor Necrosis Factor-α from Human Monocytes*
Abstract
Liver X receptor alpha (LXRalpha), is a nuclear hormone receptor that is activated by oxysterols and plays a crucial role in regulating cholesterol and lipid metabolism in liver and cholesterol efflux from lipid-loaded macrophages. Here we show that treatment of human peripheral blood monocytes or monocytic THP-1 cells with the LXR ligand 22(R)-hydroxycholesterol (22(R)-HC), in combination with 9-cis-retinoic acid (9cRA), a ligand for the LXR …
Authors
Landis MS; Patel HV; Capone JP
Journal
Journal of Biological Chemistry, Vol. 277, No. 7, pp. 4713–4721
Publisher
Elsevier
Publication Date
February 2002
DOI
10.1074/jbc.m108807200
ISSN
0021-9258
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AlitretinoinAnimalsApoptosisBase SequenceCOS CellsCell LineCells, CulturedDNA-Binding ProteinsDimerizationDose-Response Relationship, DrugHumansLigandsLiver X ReceptorsModels, GeneticMolecular Sequence DataMonocytesOrphan Nuclear ReceptorsPlasmidsPrecipitin TestsPromoter Regions, GeneticProtein BindingRNARNA, MessengerReceptors, Cytoplasmic and NuclearReceptors, Retinoic AcidReceptors, Thyroid HormoneRetinoic Acid Receptor alphaSteroidsTime FactorsTranscription, GeneticTranscriptional ActivationTransfectionTretinoinTumor Necrosis Factor-alpha