Journal article
PPAR ligands decrease human airway smooth muscle cell migration and extracellular matrix synthesis
Abstract
Airway smooth muscle cells produce extracellular matrix proteins, which in turn can promote smooth muscle survival, proliferation and migration. Currently available therapies have little effect on airway smooth muscle matrix production and migration. Peroxisome proliferator-activated receptor (PPAR) ligands are reported to decrease migration and matrix production in various cell lines. In this study, we examined the effect of PPAR ligands on …
Authors
Stephen J; Delvecchio C; Spitale N; Giesler A; Radford K; Bilan P; Cox PG; Capone JP; Nair P
Journal
European Respiratory Journal, Vol. 41, No. 2, pp. 425–432
Publisher
European Respiratory Society (ERS)
Publication Date
February 2013
DOI
10.1183/09031936.00145009
ISSN
0903-1936