Journal article
Optimization of plasma-based BioID identifies plasminogen as a ligand of ADAMTS13
Abstract
ADAMTS13, a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13, regulates the length of Von Willebrand factor (VWF) multimers and their platelet-binding activity. ADAMTS13 is constitutively secreted as an active protease and is not inhibited by circulating protease inhibitors. Therefore, the mechanisms that regulate ADAMTS13 protease activity are unknown. We performed an unbiased proteomics screen to identify ligands …
Authors
Madarati H; DeYoung V; Singh K; Sparring T; Kwong AC; Fredenburgh JC; Teney C; Koschinsky ML; Boffa MB; Weitz JI
Journal
Scientific Reports, Vol. 14, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41598-024-59672-6
ISSN
2045-2322