Cellular binding and/or uptake of nickel(II) ions.

L-Histidine (L-His) and human serum albumin (HSA) at physiological concentrations, like the exogenous ligands D-penicillamine (D-PEN) and EDTA, are shown to inhibit the uptake of physiological levels of Ni2+ by B-lymphoblasts of human origin, human erythrocytes and rabbit alveolar macrophages. Evidence is also presented that illustrates the ability of these ligands to sequester Ni2+ from cells preloaded with this ion. The experimental …