A p56 Ligand Serves as a Coactivator of an Orphan Nuclear Hormone Receptor Journal Articles uri icon

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  • Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, COUP-TFII stimulates transcription directly. A cellular factor, isolated by interaction cloning, bound COUP-TFII in vitro and allowed COUP-TFII to function as a transcriptional activator in mammalian cells. This factor is identical to a recently described ligand of the tyrosine kinase signaling molecule p56(lck), suggesting that it mediates cross-talk between mitogenic and nuclear hormone receptor signal transduction pathways.


  • Marcus, Sandra L
  • Winrow, Christopher J
  • Capone, John
  • Rachubinski, Richard A

publication date

  • November 1996

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