A p56 Ligand Serves as a Coactivator of an Orphan Nuclear Hormone Receptor Journal Articles

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abstract

Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, COUP-TFII stimulates transcription directly. A cellular factor, isolated by interaction cloning, bound COUP-TFII in vitro and allowed COUP-TFII to function as a transcriptional activator in mammalian cells. This factor is identical to a recently described ligand of the tyrosine kinase signaling molecule p56(lck), suggesting that it mediates cross-talk between mitogenic and nuclear hormone receptor signal transduction pathways.

authors

Marcus, Sandra L
Winrow, Christopher J
Capone, John
Rachubinski, Richard A

status

published

publication date

November 1996

has subject area

03 Chemical Sciences (FoR)
06 Biological Sciences (FoR)
11 Medical and Health Sciences (FoR)
Adaptor Proteins, Signal Transducing (MeSH)
Animals (MeSH)
Base Sequence (MeSH)
Binding Sites (MeSH)
Biochemistry & Molecular Biology (Science Metrix)
COUP Transcription Factor II (MeSH)
COUP Transcription Factors (MeSH)
Carrier Proteins (MeSH)
Chickens (MeSH)
Cloning, Molecular (MeSH)
DNA-Binding Proteins (MeSH)
Humans (MeSH)
Immediate-Early Proteins (MeSH)
Ligands (MeSH)
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) (MeSH)
Mammals (MeSH)
Mutagenesis, Site-Directed (MeSH)
Oligodeoxyribonucleotides (MeSH)
Proteins (MeSH)
Rats (MeSH)
Receptors, Cell Surface (MeSH)
Receptors, Cytoplasmic and Nuclear (MeSH)
Receptors, Steroid (MeSH)
Recombinant Proteins (MeSH)
Repressor Proteins (MeSH)
Sequence Deletion (MeSH)
Sequestosome-1 Protein (MeSH)
Signal Transduction (MeSH)
Trans-Activators (MeSH)
Transcription Factors (MeSH)
Transcription, Genetic (MeSH)
src-Family Kinases (MeSH)

published in

Journal of Biological Chemistry Journal