Journal article
A p56 lck Ligand Serves as a Coactivator of an Orphan Nuclear Hormone Receptor*
Abstract
Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, COUP-TFII stimulates transcription directly. A cellular factor, isolated by interaction cloning, bound COUP-TFII in vitro and allowed …
Authors
Marcus SL; Winrow CJ; Capone JP; Rachubinski RA
Journal
Journal of Biological Chemistry, Vol. 271, No. 44, pp. 27197–27200
Publisher
Elsevier
Publication Date
November 1996
DOI
10.1074/jbc.271.44.27197
ISSN
0021-9258
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptor Proteins, Signal TransducingAnimalsBase SequenceBinding SitesCOUP Transcription Factor IICOUP Transcription FactorsCarrier ProteinsChickensCloning, MolecularDNA-Binding ProteinsHumansImmediate-Early ProteinsLigandsLymphocyte Specific Protein Tyrosine Kinase p56(lck)MammalsMutagenesis, Site-DirectedOligodeoxyribonucleotidesProteinsRatsReceptors, Cell SurfaceReceptors, Cytoplasmic and NuclearReceptors, SteroidRecombinant ProteinsRepressor ProteinsSequence DeletionSequestosome-1 ProteinSignal TransductionTrans-ActivatorsTranscription FactorsTranscription, Geneticsrc-Family Kinases