Antithrombin III Concept

subject area of

• 2 Mechanisms of action of low molecular weight heparins and heparinoids  Journal Articles
• A Low-Molecular-Weight Heparinoid Compared with Unfractionated Heparin in the Prevention of Deep Vein Thrombosis in Patients with Acute Ischemic Stroke  Journal Articles
• A Placebo-controlled Randomized Trial of Antithrombin Therapy in Neonatal Respiratory Distress Syndrome  Journal Articles
• A Role for Pericellular Proteoglycan in the Binding of Thrombin or Antithrombin III by the Blood Vessel Endothelium? – The Effects of Proteoglycan-Degrading Enzymes and Glycosaminoglycan-Binding Proteins on 125I-Thrombin Binding by the Rabbit Thoracic Aorta In Vitro  Journal Articles
• A comparative evaluation of assays for markers of activated coagulation and/or fibrinolysis: thrombin–antithrombin complex, D‐dimer and fibrinogen/fibrin fragment E antigen  Journal Articles
• A dose escalation study of YM150, an oral direct factor Xa inhibitor, in the prevention of venous thromboembolism in elective primary hip replacement surgery  Journal Articles
• Activated Protein C in Ischemia-Reperfusion Injury After Experimental Lung Transplantation  Journal Articles
• Acute Effects with Reference to Thrombogenicity and Liver Toxicity after Injection of Different Coagulation Factor Concentrates  Journal Articles
• Age-related differences in heparin response  Journal Articles
• Age‐related changes in factor VII proteolysis in vivo  Journal Articles
• Alpha-2-Macroglobulin Is an Important Progressive Inhibitor of Thrombin in Neonatal and Infant Plasma  Journal Articles
• Altered inactivation of trinitrophenylated thrombin by antithrombin iii in the presence of heparin  Journal Articles
• Altered levels of antithrombin III and fibrinogen in the aortic wall of the alloxan-induced diabetic rabbit: evidence of a prothrombotic state.  Journal Articles
• An Antithrombin III Assay Based on Factor Xa Inhibition Provides a More Reliable Test to Identify Congenital Antithrombin III Deficiency Than an Assay Based on Thrombin Inhibition  Journal Articles
• An Increased Uptake of Prothrombin, Antithrombin, and Fibrinogen by the Rabbit Balloon-Deendothelialized Aorta Surface In Vivo Is Maintained Until Reendothelialization Is Complete  Journal Articles
• Anticoagulant Mechanisms of Orgaran (Org 10172) and Its Fraction with High Affinity to Antithrombin III (Org 10849)  Journal Articles
• Antithrombin III-beta associates more readily than antithrombin III-alpha with uninjured and de-endothelialized aortic wall in vitro and in vivo.  Journal Articles
• Antithrombin III‐Amiens: A new family with an Arg⁴⁷ → cys inherited variant of antithrombin iii with impaired heparin cofactor activity  Journal Articles
• Antithrombin-III-Hamilton, Ala 382 to Thr: an antithrombin-III variant that acts as a substrate but not an inhibitor of alpha-thrombin and factor Xa  Journal Articles
• Antithrombin-III-Hamilton: a gene with a point mutation (guanine to adenine) in codon 382 causing impaired serine protease reactivity  Journal Articles
• Antithrombin-III-Stockholm: a codon 392 (Gly----Asp) mutation with normal heparin binding and impaired serine protease reactivity  Journal Articles
• Antithrombotic Properties of Heparin in a Neonatal Piglet Model of Thrombin-Induced Thrombosis  Journal Articles
• Asymmetric distribution of sites with high affinity for antithrombin III in rat skin heparin proteoglycans.  Journal Articles
• BAY 59-7939: an oral, direct Factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement. A phase II dose-ranging study  Journal Articles
• Benefit of Selective Factor Inhibition  Journal Articles
• Binding of heparin to plasma proteins and endothelial surfaces is inhibited by covalent linkage to antithrombin  Journal Articles
• Blood tests for the diagnosis of venous and arterial thrombosis  Journal Articles
• Breast cancer chemotherapy induces the release of cell‐free DNA, a novel procoagulant stimulus  Journal Articles
• Catabolism of rabbit prothrombin in rabbits: uptake of prothrombin by the aorta wall before and after a de-endothelializing injury in vivo.  Journal Articles
• Central venous line–related thrombosis in children: association with central venous line location and insertion technique  Journal Articles
• Characterization of mice harboring a variant of EPCR with impaired ability to bind protein C: novel role of EPCR in hematopoiesis  Journal Articles
• Chromatography of heparin on Sepharose–lysine: molecular size fractionation and its relevance to thrombin and antithrombin III binding  Journal Articles
• Clinical presentation and molecular basis of congenital antithrombin deficiency in children: a cohort study  Journal Articles
• Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.  Journal Articles
• Comparative Pharmacodynamics and Pharmacokinetics of Oral Direct Thrombin and Factor Xa Inhibitors in Development  Journal Articles
• Comparative catabolism of prothrombin and antithrombin in normal and alloxan-diabetic rabbits  Journal Articles
• Comparative effects of heparin and LMW heparin on hemostasis  Conferences
• Comparative metabolism and distribution of rabbit heparin cofactor II and rabbit antithrombin in rabbits  Journal Articles
• Comparison of the Non-Specific Binding of Unfractionated Heparin and Low Molecular Weight Heparin (Enoxaparin) to Plasma Proteins  Journal Articles
• Comparison of the in vivo hemorrhagic and antithrombotic effects of a low antithrombin-iii affinity heparin fraction  Journal Articles
• Continuing Challenges of Sepsis Research  Journal Articles
• Contribution of Red Blood Cells to the Saturable Mechanism of Heparin Clearance  Journal Articles
• Covalent Antithrombin-Heparin Complexes with High Anticoagulant Activity  Journal Articles
• Cytokeratin 18 Is Expressed on the Hepatocyte Plasma Membrane Surface and Interacts with Thrombin-Antithrombin Complexes  Journal Articles
• D-Dimer and Thrombin-Antithrombin III Complexes in Patients with Clinically Suspected Pulmonary Embolism  Journal Articles
• Decreased Concentrations of Heparinoids Are Required to Inhibit Thrombin Generation in Plasma from Newborns and Children Compared to Plasma from Adults due to Reduced Thrombin Potential  Journal Articles
• Deendothelialization in vivo initiates a thrombogenic reaction at the rabbit aorta surface. Correlation of uptake of fibrinogen and antithrombin III with thrombin generation by the exposed subendothelium.  Journal Articles
• Discrepancy between antithrombin activity methods revealed in Antithrombin Stockholm: do factor Xa–based methods overestimate antithrombin activity in some patients?  Journal Articles
• Do Coagulation Screening Tests Detect Increased Generation of Thrombin and Plasmin in Sick Newborn Infants?  Journal Articles
• EFFECT OF SERA ON THROMBIN ACTIVATION RATE CONSTANTS: A ONE‐STAGE ASSAY OF THE EXTRINSIC SYSTEM  Journal Articles
• Effect of Atrial Fibrillation on Atrial Thrombogenesis in Humans: Impact of Rate and Rhythm  Journal Articles
• Effect of a novel covalent antithrombin-heparin complex on thrombin generation on fetal distal lung epithelium  Journal Articles
• Effect of disease and chemotherapy on hemostasis in children with acute lymphoid leukemia.  Journal Articles
• Effects of heparin fractions of different affinities to antithrombin III and thrombin on the inactivation of thrombin and factor Xa by antithrombin III  Journal Articles
• Evidence that Rabbit ¹²⁵I-Antithrombin III Binds to Proteoheparan Sulphate at the Subendothelium of the Rabbit Aorta in vitro  Journal Articles
• Expression in a cell-free system of normal and variant forms of human antithrombin III. Ability to bind heparin and react with alpha-thrombin  Journal Articles
• Fate of Thrombin and Thrombin-Antithrombin-III Complex Adsorbed to a Heparinized Biomaterial: Analysis of the Enzyme-Inhibitor Complexes Displaced by Plasma  Journal Articles
• Fibrin moderates the catalytic action of heparin but not that of dermatan sulfate on thrombin inhibition in human plasma.  Journal Articles
• Fibrinogenolysis and thrombin generation after reduced dose bolus or conventional rt-PA for pulmonary embolism. The Coagulation Project Investigators of the Bolus Alteplase Pulmonary Embolism Group.  Journal Articles
• Fondaparinux, the first selective factor Xa inhibitor  Journal Articles
• Future therapeutic directions for factor Xa inhibition in the prophylaxis and treatment of thrombotic disorders.  Journal Articles
• HEPARIN-BINDING PROTEINS - CONTRIBUTION TO HEPARIN REBOUND AFTER CARDIOPULMONARY BYPASS  Journal Articles
• Hemostasis in hypertensive disorders of pregnancy.  Journal Articles
• Hemostatic System Activation in Patients with Lupus Anticoagulant and Essential Thrombocythemia  Journal Articles
• Heparin Cofactor II and Other Endogenous Factors in the Mediation of the Antithrombotic and Anticoagulant Effects of Heparin and Dermatan Sulfate  Journal Articles
• Heparin Improves Gas Exchange during Experimental Acute Lung Injury in Newborn Piglets  Journal Articles
• Heparin and Low-Molecular-Weight Heparin  Journal Articles
• Heparin binding proteins. Contribution to heparin rebound after cardiopulmonary bypass.  Journal Articles
• Heparin clearance and ex vivo recovery in newborn piglets and adult pigs  Journal Articles
• Heparin cofactor II is more sensitive than antithrombin to secretory impairment arising from mutations introduced into its carboxy-terminal region  Journal Articles
• Heparin sensitivity and resistance in the neonate: An explanation  Journal Articles
• Heparin with low affinity to antithrombin III inhibits the activation of prothrombin in normal plasma  Journal Articles
• Heparin-Induced Thrombocytopenia: A Ten-Year Retrospective  Journal Articles
• Heparin‐induced thrombocytopenia and thrombosis: clinical and laboratory studies  Journal Articles
• Hirudin and thrombosis prophylaxis  Journal Articles
• Hirudin causes more bleeding than heparin in a rabbit ear bleeding model  Journal Articles
• IMPACT OF MUTATIONS AT THE P4 AND P5 POSITIONS ON THE REACTION OF ANTITHROMBIN WITH THROMBIN AND ELASTASE  Journal Articles
• INHIBITION OF THROMBIN BY HIRUDIN GENETICALLY FUSED TO WILD-TYPE OR MUTANT ANTITHROMBIN  Journal Articles
• INVIVO EFFECTS OF LOW-MOLECULAR-WEIGHT HEPARINS ON EXPERIMENTAL THROMBOSIS AND BLEEDING  Journal Articles
• Identification of hemostatic markers that define the pre‐DIC state: A multi‐center observational study  Journal Articles
• Immobilization of heparin on a silicone surface through a heterobifunctional PEG spacer  Journal Articles
• Impact of Chemotherapy on Thrombin Generation and on the Protein C Pathway in Breast Cancer Patients  Journal Articles
• Impact of SERPINC1 mutation on thrombotic phenotype in children with congenital antithrombin deficiency—first analysis of the International Society on Thrombosis and Haemostasis pediatric antithrombin deficiency database and biorepository  Journal Articles
• In vivo Effects of Low Molecular Weight Heparins on Experimental Thrombosis and Bleeding  Journal Articles
• In vivo behaviour of some antithrombin III-protease complexes.  Journal Articles
• Inactivation of thrombin by antithrombin III on a heparinized biomaterial  Journal Articles
• Incorporation of 7-deaza dGTP during the amplification step in the polymerase chain reaction procedure improves subsequent DNA sequencing  Journal Articles
• Inherited Thrombophilia in Ischemic Stroke and Its Pathogenic Subtypes  Journal Articles
• Inhibition of Thrombin by Antithrombin III and Heparin Cofactor II In Vivo  Journal Articles
• Inhibition of Thrombin-Neutralizing Activity of Antithrombin III by Steroid Hormones  Journal Articles
• Inhibition of factor X and factor V activation by dermatan sulfate and a pentasaccharide with high affinity for antithrombin III in human plasma  Journal Articles
• Inhibition of factor X, factor V and prothrombin activation by the bis(lactobionic acid amide) LW10082  Journal Articles
• Inhibition of thrombin by antithrombin III in the presence of certain glycosaminoglycans found in the mammalian aorta  Journal Articles
• Intracellular events determine the fate of antithrombin Utah  Journal Articles
• Management of anti-thrombin III deficiency during pregnancy without administration of anti-thrombin III  Journal Articles
• Measurement of Markers of Activated Coagulation in Antithrombin III Deficient Subjects  Journal Articles
• Measurement of factor Xa‐antithrombin III in plasma: relationship to prothrombin activation in vivo  Journal Articles
• Mechanisms Responsible for Catalysis of the Inhibition of Factor Xa or Thrombin by Antithrombin Using a Covalent Antithrombin-Heparin Complex  Journal Articles
• Mechanisms for Inhibition of the Generation of Thrombin Activity by Sulfated Polysaccharides^a  Journal Articles
• Mechanisms for the anticoagulant effect of heparin and related polysaccharides.  Journal Articles
• Mixing study to diagnose heparin‐resistance caused by functional antithrombin deficiency  Journal Articles
• Molecular Cloning and Cell-Free Expression of Mouse Antithrombin III  Journal Articles
• Molecular cloning and expression of rabbit antithrombin III  Journal Articles
• Molecular structural analysis of a novel and de‐novo mutation in the SERPINC1 gene associated with type 1 antithrombin deficiency  Journal Articles
• New Anticoagulant Therapy  Journal Articles
• New Anticoagulants  Journal Articles
• New Antithrombotic Drugs  Journal Articles
• No Association Between Protein C Levels and Bacteremia in Children With Febrile Neutropenia  Journal Articles
• On the interaction of rabbit antithrombin III with the luminal surface of the normal and deendothelialized rabbit thoracic aorta in vitro  Journal Articles
• Ontogeny of mouse and rat antithrombin III  Journal Articles
• Pentasaccharide Org31540/SR90107A clinical trials update: Lessons for practice  Journal Articles
• Peptide modified gold-coated polyurethanes as thrombin scavenging surfaces  Journal Articles
• Plasma Anticoagulant Mechanisms of Heparin, Heparan Sulfate, and Dermatan Sulfatea  Journal Articles
• Plasma factor VII and thrombin–antithrombin III levels indicate increased tissue factor activity in sickle cell patients  Journal Articles
• Pre-operative Plasma Levels of Thrombin-Antithrombin III Complexes Correlate with the Development of Venous Thrombosis after Major Hip or Knee Surgery  Journal Articles
• Preliminary study to identify cancer patients at high risk of venous thrombosis following major surgery  Journal Articles
• Prevention of Recurrent Venous Thrombosis: Warfarin versus Heparin  Journal Articles
• Prevention of Thrombus Growth by Antithrombin III-Dependent and Two Direct Thrombin Inhibitors in Rabbits: Implications for Antithrombotic Therapy  Journal Articles
• Prevention of thrombus formation and growth by antithrombin III and heparin cofactor II-dependent thrombin inhibitors: Importance of heparin cofactor II  Journal Articles
• Probable regulation of factor VIIa–tissue factor and prothrombinase by factor Xa–TFPI and TFPI in vivo  Journal Articles
• Prophylactically equivalent doses of Enoxaparin and unfractionated heparin inhibit in vivo coagulation to the same extent  Journal Articles
• Rationale Behind the Development of Low Molecular Weight Heparin Derivatives  Journal Articles
• Reactivation of coagulation after stopping infusions of recombinant hirudin and unfractionated heparin in unstable angina and myocardial infarction without ST elevation: results of a randomized trial  Journal Articles
• Report of the ISHLT Working Group on Primary Lung Graft Dysfunction Part VI: Treatment  Journal Articles
• Requirement of Lysine Residues Outside of the Proposed Pentasaccharide Binding Region for High Affinity Heparin Binding and Activation of Human Antithrombin III  Journal Articles
• Respective role of antithrombin III and heparin cofactor II in the in vitro anticoagulant effect of heparin and of various sulphated polysaccharides  Journal Articles
• Site‐directed mutagenesis of alanine‐382 of human antithrombin III  Journal Articles
• Standard assays underestimate the concentration of heparin in neonatal plasma.  Journal Articles
• Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function  Journal Articles
• Thalidomide‐prednisone maintenance following autologous stem cell transplant for Multiple Myeloma: effect on thrombin generation and procoagulant markers in NCIC CTG MY.10  Journal Articles
• The N-terminal domain of antithrombin-III is essential for heparin binding and complex-formation with, but not cleavage by, α-thrombin  Journal Articles
• The Asp272–Glu282 Region of Platelet Glycoprotein Ibα Interacts with the Heparin-binding Site of α-Thrombin and Protects the Enzyme from the Heparin-catalyzed Inhibition by Antithrombin III  Journal Articles
• The Effect of Antithrombin III-Independent Thrombin Inhibitors and Heparin on Fibrin Accretion onto Fibrin-Coated Polyethylene \textbar Request PDF  Journal Articles
• The Effects of Hormone Replacement Therapy on Thrombin Generation, Fibrinolysis Inhibition, and Resistance to Activated Protein C  Journal Articles
• The Molecular Pathology of Inherited Human Antithrombin III Deficiency  Journal Articles
• The comparison of the pharmacokinetics of a low molecular weight heparin in the newborn and adult pig  Journal Articles
• The effects of high-dose heparin on inflammatory and coagulation parameters following cardiopulmonary bypass  Journal Articles
• The hypercoagulable state in cancer patients  Journal Articles
• The importance of thrombin inhibition for the expression of the anticoagulant activities of heparin, dermatan sulphate, low molecular weight heparin and pentosan polysulphate  Journal Articles
• The influence of heparin, NaCl and CaCl2 on the rate of the thrombin-antithrombin III reaction  Journal Articles
• The inhibition by heparin of the intrinsic pathway activation of factor X in the absence of antithrombin-III  Journal Articles
• The inhibition of the anticoagulant activity of heparin by platelets, brain phospholipids, and tissue factor  Journal Articles
• The low molecular weight heparin Enoxaparin inhibits the consumption of factor VII and prothrombin activation in vivo associated with elective knee replacement surgery  Journal Articles
• Thrombin Binds to Soluble Fibrin Degradation Products Where it Is Protected From Inhibition by Heparin-Antithrombin but Susceptible to Inactivation by Antithrombin-Independent Inhibitors  Journal Articles
• Thrombin Generation during Cardiac Surgery: Is Heparin the Ideal Anticoagulant?  Journal Articles
• Thrombin Inhibition Is Impaired in Plasma of Sick Neonates  Journal Articles
• Thrombin/Antithrombin III Complex Formation in the Neonatal Respiratory Distress Syndrome  Journal Articles
• Treatment of Proximal Deep Vein Thrombosis With a Novel Synthetic Compound (SR90107A/ORG31540) With Pure Anti–Factor Xa Activity  Journal Articles
• Trinucleotide repeat polymorphism within the human antithrombin gene (AT3): allele frequency data for three population groups  Journal Articles
• Unfractionated heparin inhibits thrombin-catalysed amplification reactions of coagulation more efficiently than those catalysed by factor Xa  Journal Articles
• Use of a Fixed Activated Partial Thromboplastin Time Ratio to Establish a Therapeutic Range for Unfractionated Heparin  Journal Articles
• Use of low molecular mass heparin (enoxaparin) in newborn infants: a prospective cohort study of 62 patients  Journal Articles
• Vascular Endothelial Tissue Factor Pathway Inhibitor Kinetics in Culture Following Exposure to DX-9065a—A Selective and Direct Factor Xa Inhibitor  Journal Articles
• Warfarin Cessation Before Cardiopulmonary Bypass: Lessons Learned from a Randomized Controlled Trial of Oral Vitamin K  Journal Articles
• Warfarin-induced venous limb ischemia/gangrene complicating cancer: a novel and clinically distinct syndrome  Journal Articles
• Whole blood heparin concentrations do not correlate with plasma antifactor Xa heparin concentrations in pediatric patients undergoing cardiopulmonary bypass  Journal Articles
• c.1058C>T variant in the SERPINC1 gene is pathogenic for antithrombin deficiency  Journal Articles
• α2-Macroglobulin Remains as Important as Antithrombin III for Thrombin Regulation in Cord Plasma in the Presence of Endothelial Cell Surfaces  Journal Articles