Journal article
Heparin clearance and ex vivo recovery in newborn piglets and adult pigs
Abstract
The newborn infant requires more heparin per kg body weight than the adult to achieve similar heparin plasma levels. Possible mechanisms include altered heparin pharmacokinetics and/or a decreased expression of anticoagulant activity of heparin in new-born plasma because of low levels of antithrombin III (AT-III). We measured the pharmacokinetics and the anticoagulant activity of heparin in the pig (AT-III level: 100%), in the piglet (levels of …
Authors
Andrew M; Ofosu F; Schmidt B; Brooker L; Hirsh J; Buchanan MR
Journal
Thrombosis Research, Vol. 52, No. 6, pp. 517–527
Publisher
Elsevier
Publication Date
December 1988
DOI
10.1016/0049-3848(88)90125-9
ISSN
0049-3848