Journal article
Reactivation of coagulation after stopping infusions of recombinant hirudin and unfractionated heparin in unstable angina and myocardial infarction without ST elevation: results of a randomized trial
Abstract
AIMS: To compare effects of heparin and hirudin on biochemical markers of coagulation.
METHODS AND RESULTS: Patients (n=395) with unstable angina or myocardial infarction without ST elevation were randomized to a 72-h infusion of one of three regimens: unfractionated heparin (bolus of 5000 IU followed by an infusion of 1200 IU. h(-1)), low-dose hirudin (HBW 023; 0.2 mg. kg(-1)bolus followed by 0.10 mg. kg(-1). h(-1)) or medium-dose hirudin (0.4 …
Authors
Flather MD; Weitz JI; Yusuf S; Pogue J; Sussex B; Campeau J; Gill J; Schuld R; Joyner CD; Morris AL
Journal
European Heart Journal, Vol. 21, No. 17, pp. 1473–1481
Publisher
Oxford University Press (OUP)
Publication Date
September 1, 2000
DOI
10.1053/euhj.1999.2005
ISSN
0195-668X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Angina, UnstableAnticoagulantsAntithrombin IIIAntithrombinsBiomarkersBlood CoagulationCanadaDrug Administration ScheduleElectrocardiographyFemaleFibrinolytic AgentsHeparinHirudinsHumansInfusions, IntravenousMaleMiddle AgedMyocardial InfarctionPartial Thromboplastin TimePeptide FragmentsProthrombinRecombinant Proteins