Warfarin-induced venous limb ischemia/gangrene complicating cancer: a novel and clinically distinct syndrome Journal Articles

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abstract

Key PointsWarfarin-induced venous gangrene in cancer affects limb with DVT and features platelet fall after stopping heparin and supratherapeutic INR. Persisting thrombin generation occurs despite elevated INR, indicating severe PC depletion that occurs in parallel with reduced factor VII.

authors

Warkentin, Ted
Cook, Richard J
Sarode, Ravi
Sloane, Debi A
Crowther, Mark

status

published

publication date

July 23, 2015

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Aged (MeSH)
Anticoagulants (MeSH)
Antithrombin III (MeSH)
Blood Coagulation Factors (MeSH)
Blood Platelets (MeSH)
Female (MeSH)
Follow-Up Studies (MeSH)
Gangrene (MeSH)
Heparin (MeSH)
Humans (MeSH)
Immunology (Science Metrix)
International Normalized Ratio (MeSH)
Ischemia (MeSH)
Leg (MeSH)
Male (MeSH)
Middle Aged (MeSH)
Neoplasms (MeSH)
Peptide Hydrolases (MeSH)
Prognosis (MeSH)
Protein C Deficiency (MeSH)
Syndrome (MeSH)
Venous Thrombosis (MeSH)
Vitamin K (MeSH)
Warfarin (MeSH)

published in

Blood Journal