Journal article
Activated Protein C in Ischemia-Reperfusion Injury After Experimental Lung Transplantation
Abstract
BACKGROUND: Ischemia-reperfusion injury remains the major cause of early morbidity and mortality after lung transplantation. Activated protein C (APC) has been demonstrated to attenuate various acute inflammation-related injuries in the lung and other organs.
METHODS: The effect of exogenous APC in lung transplantation was examined using a rat orthotopic lung transplantation model of ischemia-reperfusion injury with 24 hours of cold ischemia. …
Authors
Hirayama S; Cypel M; Sato M; Anraku M; Liaw PC; Liu M; Waddell TK; Keshavjee S
Journal
The Journal of Heart and Lung Transplantation, Vol. 28, No. 11, pp. 1180–1184
Publisher
Elsevier
Publication Date
November 2009
DOI
10.1016/j.healun.2009.06.026
ISSN
1053-2498