Covalent Antithrombin-Heparin Complexes with High Anticoagulant Activity INTRAVENOUS, SUBCUTANEOUS, AND INTRATRACHEAL ADMINISTRATION*

Although heparin has been used clinically for prophylaxis and treatment of thrombosis, it has suffered from problems such as short duration within compartments in vivo that require long term anticoagulation. A covalent antithrombin-heparin complex has been produced with high anticoagulant activity and a long half-life relative to heparin. The product had high anti-factor Xa and antithrombin activities compared with noncovalent mixtures of …