Journal article
Anticoagulant Mechanisms of Orgaran (Org 10172) and Its Fraction with High Affinity to Antithrombin III (Org 10849)
Abstract
Orgaran (Org 10172), which has antithrombotic activity in man with apparently minimal bleeding side effects, is a mixture of low-molecular-weight heparan, dermatan, and chondroitin sulfates. The degrees to which the minimum concentrations of Orgaran, its fraction with high affinity for antithrombin III (Org 10849; AT III) and unfractionated heparin, which double the activated partial thromboplastin time (APTT) of pooled normal plasma, inhibit …
Authors
Ofosu FA
Journal
Pathophysiology of Haemostasis and Thrombosis, Vol. 22, No. 2, pp. 66–72
Publisher
Karger Publishers
Publication Date
1992
DOI
10.1159/000216297
ISSN
1424-8832