Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function Journal Articles

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abstract

Key PointsJuvenile zebrafish tolerate widespread coagulopathy due to complete ablation of antithrombin III, but develop lethal thrombosis as adults. In vivo structure/function analysis of antithrombin III in zebrafish reveals limited roles for heparin-binding and anti-IXa/Xa activity.

authors

Liu, Yang
Kretz, Colin
Maeder, Morgan L
Richter, Catherine E
Tsao, Philip
Vo, Andy H
Huarng, Michael C
Rode, Thomas
Hu, Zhilian
Mehra, Rohit
Olson, Steven T
Joung, J Keith
Shavit, Jordan A

status

published

publication date

July 3, 2014

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Animals (MeSH)
Animals, Genetically Modified (MeSH)
Antithrombin III (MeSH)
Antithrombin III Deficiency (MeSH)
Disease Models, Animal (MeSH)
Disseminated Intravascular Coagulation (MeSH)
Humans (MeSH)
Immunology (Science Metrix)
In Situ Hybridization (MeSH)
Mutagenesis, Site-Directed (MeSH)
Reverse Transcriptase Polymerase Chain Reaction (MeSH)
Zebrafish (MeSH)
Zebrafish Proteins (MeSH)

published in

Blood Journal