Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function Academic Article uri icon

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abstract

  • Key Points Juvenile zebrafish tolerate widespread coagulopathy due to complete ablation of antithrombin III, but develop lethal thrombosis as adults. In vivo structure/function analysis of antithrombin III in zebrafish reveals limited roles for heparin-binding and anti-IXa/Xa activity.

authors

  • Liu, Yang
  • Kretz, Colin
  • Maeder, Morgan L
  • Richter, Catherine E
  • Tsao, Philip
  • Vo, Andy H
  • Huarng, Michael C
  • Rode, Thomas
  • Hu, Zhilian
  • Mehra, Rohit
  • Olson, Steven T
  • Joung, J Keith
  • Shavit, Jordan A

publication date

  • July 3, 2014

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