Protein Serine-Threonine Kinases Concept

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• Chlamydophila pneumoniae PknD Exhibits Dual Amino Acid Specificity and Phosphorylates Cpn0712, a Putative Type III Secretion YscD Homolog  Journal Articles
• IL‐6 mediates ER expansion during hyperpolarization of alternatively activated macrophages  Journal Articles
• A Multiplex Human Syndrome Implicates a Key Role for Intestinal Cell Kinase in Development of Central Nervous, Skeletal, and Endocrine Systems  Journal Articles
• A Novel Non-canonical Forkhead-associated (FHA) Domain-binding Interface Mediates the Interaction between Rad53 and Dbf4 Proteins  Journal Articles
• A Phase I Open-Label Dose-Escalation Study of Intravenous BI 2536 Together With Pemetrexed in Previously Treated Patients With Non–Small-Cell Lung Cancer  Journal Articles
• A Randomized, Open-Label Phase II Trial of Volasertib as Monotherapy and in Combination With Standard-Dose Pemetrexed Compared With Pemetrexed Monotherapy in Second-Line Treatment for Non–Small-Cell Lung Cancer  Journal Articles
• A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia  Journal Articles
• AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5  Journal Articles
• AMP-activated protein kinase — the fat controller of the energy railroadThis paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference.  Journal Articles
• AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment  Journal Articles
• ATM activation is accompanied with earlier stages of prostate tumorigenesis  Journal Articles
• ATM activity contributes to the tumor-suppressing functions of p14ARF  Journal Articles
• ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes  Journal Articles
• ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance  Journal Articles
• Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia  Journal Articles
• Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish  Journal Articles
• Abrogation of mesenchyme-specific TGF-β signaling results in lung malformation with prenatal pulmonary cysts in mice  Journal Articles
• Absence of a differentiation defect in muscle satellite cells from DM2 patients  Journal Articles
• Adiponectin: Starving for Attention  Journal Articles
• Akt Is Activated in Response to an Apoptotic Signal  Journal Articles
• Akt Mediates Mechanical Strain-Induced Collagen Production by Mesangial Cells  Journal Articles
• Allelic and phenotypic spectrum of plasma triglycerides  Journal Articles
• Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling  Journal Articles
• Aminoglycoside antibiotic phosphotransferases are also serine protein kinases  Journal Articles
• An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator  Journal Articles
• Association of Neurofilament Proteins with Neuronal Cdk5 Activator  Journal Articles
• Bone Morphogenetic Proteins Regulate the Developmental Program of Human Hematopoietic Stem Cells  Journal Articles
• Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation  Journal Articles
• Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK  Journal Articles
• CANTRK  Journal Articles
• CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection  Journal Articles
• CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK  Journal Articles
• Carbohydrate refeeding after a high-fat diet rapidly reverses the adaptive increase in human skeletal muscle PDH kinase activity  Journal Articles
• Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells  Journal Articles
• Ciliary Neurotrophic Factor Suppresses Hypothalamic AMP-Kinase Signaling in Leptin-Resistant Obese Mice  Journal Articles
• Compromised genomic integrity impedes muscle growth after Atrx inactivation  Journal Articles
• Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase  Journal Articles
• Cyclin-dependent Kinase 5 (Cdk5) Activation Domain of Neuronal Cdk5 Activator  Journal Articles
• Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators  Journal Articles
• Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators  Chapters
• DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants  Journal Articles
• DRD2/ANKK1 TaqI A genotype moderates the relationship between alexithymia and the relative value of alcohol among male college binge drinkers  Journal Articles
• Deletion of Macrophage-Specific Glycogen Synthase Kinase (GSK)-3α Promotes Atherosclerotic Regression in Ldlr−/− Mice  Journal Articles
• Distinct surfaces on Cdc5/PLK Polo-box domain orchestrate combinatorial substrate recognition during cell division  Journal Articles
• Down‐regulated miRs specifically correlate with non‐cardial gastric cancers and Lauren's classification system  Journal Articles
• Dual roles of parathyroid hormone related protein in TGF-β1 signaling and fibronectin up-regulation in mesangial cells  Journal Articles
• ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53  Journal Articles
• ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function  Journal Articles
• ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation  Journal Articles
• Effects of aerobic training on pyruvate dehydrogenase and pyruvate dehydrogenase kinase in human skeletal muscle  Journal Articles
• Elevated n-3 fatty acids in a high-fat diet attenuate the increase in PDH kinase activity but not PDH activity in human skeletal muscle  Journal Articles
• Endothelin-1 axis fosters YAP-induced chemotherapy escape in ovarian cancer  Journal Articles
• Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-β type II receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF-AA  Journal Articles
• Establishing a relationship between prolactin and altered fatty acid β-Oxidation via carnitine palmitoyl transferase 1 in breast cancer cells  Journal Articles
• Excitation-contraction coupling in pulmonary vascular smooth muscle involves tyrosine kinase and Rho kinase  Journal Articles
• Exercising women throw a wrench in the gears of the AMPK–lipid oxidation link  Journal Articles
• Expression of recombinant human casein kinase II and recombinant heat shock protein 90 in Escherichia coli and characterization of their interactions.  Journal Articles
• Fatty acids stimulate AMP‐activated protein kinase and enhance fatty acid oxidation in L6 myotubes  Journal Articles
• Functional analysis of CfSnf1 in the development and pathogenicity of anthracnose fungus Colletotrichum fructicola on tea-oil tree  Journal Articles
• G Protein-coupled Receptor Kinase-mediated Desensitization of Metabotropic Glutamate Receptor 1A Protects against Cell Death  Journal Articles
• Genetic determinants of plasma triglycerides  Journal Articles
• Genetic influences on delay discounting in smokers: examination of a priori candidates and exploration of dopamine-related haplotypes  Journal Articles
• Glucose transporter expression in L6 muscle cells: Regulation through insulin- and stress-activated pathways  Journal Articles
• Glycosyltransferases and Glycosaminoglycans in Bleomycin and Transforming Growth Factor-β1–Induced Pulmonary Fibrosis  Journal Articles
• Guanosine protects SH-SY5Y cells against β-amyloid-induced apoptosis  Journal Articles
• HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function  Journal Articles
• Hierarchical investigation of genetic influences on response inhibition in healthy young adults.  Journal Articles
• Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression  Journal Articles
• Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet  Journal Articles
• Human skeletal muscle pyruvate dehydrogenase kinase activity increases after a low-carbohydrate diet  Journal Articles
• Hyperglycemia Exacerbates Burn-Induced Liver Inflammation via Noncanonical Nuclear Factor-κB Pathway Activation  Journal Articles
• Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells  Journal Articles
• Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression  Journal Articles
• Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition  Journal Articles
• Inflammation promotes adipocyte lipolysis via IRE1 kinase  Journal Articles
• Inhibition of apoptosis in human induced pluripotent stem cells during expansion in a defined culture using angiopoietin-1 derived peptide QHREDGS  Journal Articles
• Insulin Activates a p21-activated Kinase in Muscle Cells via Phosphatidylinositol 3-Kinase  Journal Articles
• Insulin, Insulin-like Growth Factor-I, and Platelet-Derived Growth Factor Activate Extracellular Signal-Regulated Kinase by Distinct Pathways in Muscle Cells  Journal Articles
• Interaction of Cyclin-dependent Kinase 5 (Cdk5) and Neuronal Cdk5 Activator in Bovine Brain  Journal Articles
• Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase  Journal Articles
• Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells  Journal Articles
• Isoprostane-induced airway hyperresponsiveness is dependent on internal Ca²⁺ handling and Rho/ROCK signaling  Journal Articles
• KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase  Journal Articles
• Liver kinase B1 expression (LKB1) is repressed by estrogen receptor alpha (ERα) in MCF-7 human breast cancer cells  Journal Articles
• Loss of Hepatocyte-Nuclear-Factor-1α Impacts on Adult Mouse Intestinal Epithelial Cell Growth and Cell Lineages Differentiation  Journal Articles
• Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells  Journal Articles
• MRE11–RAD50–NBS1 and ATM function as co-mediators of TRF1 in telomere length control  Journal Articles
• Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo  Journal Articles
• Melatonin and Hippo Pathway: Is There Existing Cross-Talk?  Journal Articles
• Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation  Journal Articles
• Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK  Journal Articles
• Mirk/Dyrk1b Mediates Cell Survival in Rhabdomyosarcomas  Journal Articles
• Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin M in murine fibroblasts  Journal Articles
• Multiple Signaling Pathways Control the Activation of the CEF-4/9E3 Cytokine Gene by pp60v-  Journal Articles
• Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft.  Journal Articles
• Muscarinic excitation-contraction coupling mechanisms in tracheal and bronchial smooth muscles  Journal Articles
• Muscle fiber type comparison of PDH kinase activity and isoform expression in fed and fasted rats  Journal Articles
• Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers  Journal Articles
• Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop  Journal Articles
• Mutations in TBCK, Encoding TBC1-Domain-Containing Kinase, Lead to a Recognizable Syndrome of Intellectual Disability and Hypotonia  Journal Articles
• NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence  Journal Articles
• Negative Regulation of β4 Integrin Transcription by Homeodomain-Interacting Protein Kinase 2 and p53 Impairs Tumor Progression  Journal Articles
• Neuronal Cdc2-like kinase: from cell cycle to neuronal function  Journal Articles
• Non-digestible oligosaccharides directly regulate host kinome to modulate host inflammatory responses without alterations in the gut microbiota  Journal Articles
• Novel Function of PERK as a Mediator of Force-induced Apoptosis  Journal Articles
• Nuclear Import of Cdk/Cyclin Complexes: Identification of Distinct Mechanisms for Import of Cdk2/Cyclin E and Cdc2/Cyclin B1  Journal Articles
• Nuclear Targeting of Methyl-Recycling Enzymes in Arabidopsis thaliana Is Mediated by Specific Protein Interactions  Journal Articles
• Nucleotide Selectivity of Antibiotic Kinases  Journal Articles
• Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children  Journal Articles
• Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death  Journal Articles
• Phosphorylation of PITSLRE p110 Isoforms Accompanies Their Processing by Caspases during Fas-mediated Cell Death  Journal Articles
• Polo-Like Kinase 1 Inhibition Kills Glioblastoma Multiforme Brain Tumor Cells in Part Through Loss of SOX2 and Delays Tumor Progression in Mice  Journal Articles
• Polo-like kinases in AML  Journal Articles
• Polygenic determinants of severe hypertriglyceridemia  Journal Articles
• Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms  Journal Articles
• Progressive Transforming Growth Factor β1–induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor  Journal Articles
• Pyruvate overrides inhibition of PDH during exercise after a low-carbohydrate diet  Journal Articles
• Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise  Journal Articles
• Reduced glycogen availability is associated with increased AMPKα2 activity, nuclear AMPKα2 protein abundance, and GLUT4 mRNA expression in contracting human skeletal muscle  Journal Articles
• Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue  Journal Articles
• Regulation of NADH/CoQ Oxidoreductase: Do Phosphorylation Events Affect Activity?  Journal Articles
• Regulation of Rho/ROCK signaling in airway smooth muscle by membrane potential and [Ca²⁺]_i  Journal Articles
• Regulation of airway smooth muscle RhoA/ROCK activities by cholinergic and bronchodilator stimuli  Journal Articles
• Regulation of airway smooth muscle RhoA/ROCK activities by cholinergic and bronchodilator stimuli.  Journal Articles
• Regulatory properties of neuronal cdc2-like kinase  Journal Articles
• Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers  Journal Articles
• Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown  Journal Articles
• Role of PRY-1/Axin in heterochronic miRNA-mediated seam cell development  Journal Articles
• S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3  Journal Articles
• Selective involvement of the PI3K/PKB/bad pathway in retinal cell death  Journal Articles
• Semaphorin 3F Antagonizes Neurotrophin-Induced Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Kinase Signaling: A Mechanism for Growth Cone Collapse  Journal Articles
• Serum- and Glucocorticoid-Regulated Kinase 1 Is Required for Nuclear Export of the Ribonucleoprotein of Influenza A Virus  Journal Articles
• Signals for local and systemic responses of plants to pathogen attack  Journal Articles
• Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise  Journal Articles
• Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype  Journal Articles
• Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion  Journal Articles
• StoPK-1, a serine/threonine protein kinase from the glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009, affects oxidative stress response  Journal Articles
• Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy.  Journal Articles
• Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf  Journal Articles
• Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits  Journal Articles
• TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model  Journal Articles
• TGF-  receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung  Journal Articles
• TGF-β and Smad3 Signaling Link Inflammation to Chronic Fibrogenesis  Journal Articles
• The AMP-Activated Protein Kinase: Role in Regulation of Skeletal Muscle Metabolism and Insulin Sensitivity  Journal Articles
• The Hippo tumor suppressor pathway: a report on ‘the second workshop on the Hippo tumor suppressor pathway’  Journal Articles
• The Stimulatory Effect of Globular Adiponectin on Insulin-Stimulated Glucose Uptake and Fatty Acid Oxidation Is Impaired in Skeletal Muscle From Obese Subjects  Journal Articles
• The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades.  Journal Articles
• The acute effects of differential dietary fatty acids on human skeletal muscle pyruvate dehydrogenase activity  Journal Articles
• The antiapoptotic effect of guanosine is mediated by the activation of the PI 3‐kinase/AKT/PKB pathway in cultured rat astrocytes  Journal Articles
• The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-β type II receptor gene transfer  Journal Articles
• The p38-MK2-HuR pathway potentiates EGFRvIII–IL-1β-driven IL-6 secretion in glioblastoma cells  Journal Articles
• The relationship between human skeletal muscle pyruvate dehydrogenase phosphatase activity and muscle aerobic capacity  Journal Articles
• The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells  Journal Articles
• The unfolded protein response is triggered following a single, unaccustomed resistance-exercise bout  Journal Articles
• Therapeutic Targeting of the Premetastatic Stage in Human Lung-to-Brain Metastasis  Journal Articles
• Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo  Journal Articles
• Vasoconstrictor actions of isoprostanes via tyrosine kinase and Rho kinase in human and canine pulmonary vascular smooth muscles  Journal Articles
• WTAP and m6A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells  Journal Articles
• Whole Blood Gene Expression Differentiates between Atrial Fibrillation and Sinus Rhythm after Cardioversion  Journal Articles
• Whole‐exome sequencing is a valuable diagnostic tool for inherited peripheral neuropathies: Outcomes from a cohort of 50 families  Journal Articles
• YAP1 Meets Tumor Suppression  Journal Articles
• miRNA in the Regulation of Skeletal Muscle Adaptation to Acute Endurance Exercise in C57Bl/6J Male Mice  Journal Articles
• miR‐10b*, a master inhibitor of the cell cycle, is down‐regulated in human breast tumours  Journal Articles
• β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer  Journal Articles
• β‐adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling  Journal Articles