Journal article
A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia
Abstract
Numerous single nucleotide polymorphisms (SNPs) have been found in recent genome wide association studies (GWAS) to be associated with subtle plasma triglyceride (TG) variation in normolipidemic subjects. However, since these GWAS did not specifically evaluate patients with rare disorders of lipoprotein metabolism--'hyperlipoproteinemia' (HLP)--it remains largely unresolved whether any of these SNP determinants of modest physiological changes …
Authors
Hegele RA; Ban MR; Hsueh N; Kennedy BA; Cao H; Zou GY; Anand S; Yusuf S; Huff MW; Wang J
Journal
Human Molecular Genetics, Vol. 18, No. 21, pp. 4189–4194
Publisher
Oxford University Press (OUP)
Publication Date
November 1, 2009
DOI
10.1093/hmg/ddp361
ISSN
0964-6906
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptor Proteins, Signal TransducingAdultAgedAngiopoietin-Like Protein 3Angiopoietin-like ProteinsAngiopoietinsApolipoprotein A-VApolipoproteins ACalcium-Calmodulin-Dependent Protein KinasesFemaleGTP-Binding ProteinsGene FrequencyGenome-Wide Association StudyGenotypeHumansHyperlipoproteinemiasHypertriglyceridemiaIntracellular Signaling Peptides and ProteinsLinkage DisequilibriumLogistic ModelsMaleMiddle AgedMultifactorial InheritanceMultivariate AnalysisN-AcetylgalactosaminyltransferasesPhenotypePolymorphism, Single NucleotideProtein Serine-Threonine KinasesTriglyceridesPolypeptide N-acetylgalactosaminyltransferase