Journal article
Dual roles of parathyroid hormone related protein in TGF-β1 signaling and fibronectin up-regulation in mesangial cells
Abstract
Little is known about the cross-talk between parathyroid hormone (PTH) related protein (PTHrP) and TGF-β1 in mesangial cells (MCs). Our results showed that PTHrP treatment (≤3 h) induced internalization of PTH1R (PTH/PTHrP receptor)-TβRII (TGF-β type 2 receptor) complex and suppressed TGF-β1-mediated Smad2/3 activation and fibronectin (FN) up-regulation. However, prolonged PTHrP treatment (12-48 h) failed to induce PTH1R-TβRII association and …
Authors
Wu S-Z; Yang S-J; Chen H-M; Peng F-F; Yu H; Krepinsky JC; Zhang B-F
Journal
Bioscience Reports, Vol. 37, No. 5,
Publisher
Portland Press
Publication Date
October 31, 2017
DOI
10.1042/bsr20171061
ISSN
0144-8463
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Diabetic NephropathiesFibronectinsHumansMesangial CellsParathyroid HormoneParathyroid Hormone-Related ProteinProtein Serine-Threonine KinasesReceptor, Parathyroid Hormone, Type 1Receptor, Transforming Growth Factor-beta Type IIReceptors, Transforming Growth Factor betaSignal TransductionTransforming Growth Factor beta1