Journal article
Regulation of NADH/CoQ Oxidoreductase: Do Phosphorylation Events Affect Activity?
Abstract
We had previously suggested that phosphorylation of proteins by mitochondrial kinases regulate the activity of NADH/CoQ oxidoreductase. Initial data showed that pyruvate dehydrogenase kinase (PDK) and cAMP-dependent protein kinase A (PKA) phosphorylate mitochondrial membrane proteins. Upon phosphorylation with crude PDK, mitochondria appeared to be deficient in NADH/cytochrome c reductase activity associated with increased superoxide …
Authors
Maj MC; Raha S; Myint T; Robinson BH
Journal
The Protein Journal, Vol. 23, No. 1, pp. 25–32
Publisher
Springer Nature
Publication Date
January 2004
DOI
10.1023/b:jopc.0000016255.17077.2c
ISSN
1572-3887
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenosine TriphosphateAmino Acid SequenceAnimalsCattleCyclic AMP-Dependent Protein KinasesElectron Transport Complex IEnzyme ActivationHumansIsoenzymesKetone OxidoreductasesMitochondria, HeartMolecular Sequence DataNADPhosphorylationProtein KinasesProtein Serine-Threonine KinasesPyruvate Dehydrogenase Acetyl-Transferring KinaseRatsRecombinant ProteinsSequence AlignmentSuperoxidesSwine