Journal article
ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance
Abstract
Ataxia telangiectasia mutated (ATM), a PI-3 kinase essential for maintaining genomic stability, has been shown to regulate TRF1, a negative mediator of telomerase-dependent telomere extension. However, little is known about ATM-mediated TRF1 phosphorylation site(s) in vivo. Here, we report that ATM phosphorylates S367 of TRF1 and that this phosphorylation renders TRF1 free of chromatin. We show that phosphorylated (pS367)TRF1 forms distinct …
Authors
McKerlie M; Lin S; Zhu X-D
Journal
Nucleic Acids Research, Vol. 40, No. 9, pp. 3975–3989
Publisher
Oxford University Press (OUP)
Publication Date
May 1, 2012
DOI
10.1093/nar/gks035
ISSN
0305-1048
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Ataxia Telangiectasia Mutated ProteinsCell CycleCell Cycle ProteinsCell LineCell NucleusDNA-Binding ProteinsHumansMutationPhosphorylationProteasome Endopeptidase ComplexProteasome InhibitorsProtein Serine-Threonine KinasesTelomeraseTelomereTelomere HomeostasisTelomeric Repeat Binding Protein 1Tumor Suppressor Proteins