Journal article
Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells
Abstract
PURPOSE: Adenosine monophosphate (AMP)-activated kinase (AMPK) is a molecular energy sensor regulated by the tumor suppressor LKB1. Starvation and growth factors activate AMPK through the DNA damage sensor ataxia-telangiectasia mutated (ATM). We explored the regulation of AMPK by ionizing radiation (IR) and its role as a target for radiosensitization of human cancer cells.
METHODS AND MATERIALS: Lung, prostate, and breast cancer cells were …
Authors
Sanli T; Rashid A; Liu C; Harding S; Bristow RG; Cutz J-C; Singh G; Wright J; Tsakiridis T
Journal
International Journal of Radiation Oncology • Biology • Physics, Vol. 78, No. 1, pp. 221–229
Publisher
Elsevier
Publication Date
September 2010
DOI
10.1016/j.ijrobp.2010.03.005
ISSN
0360-3016
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AMP-Activated Protein KinasesAtaxia Telangiectasia Mutated ProteinsBreast NeoplasmsCell Cycle ProteinsCell Line, TumorCell SurvivalCyclin-Dependent Kinase Inhibitor p21DNA-Binding ProteinsEnzyme ActivationFemaleG2 PhaseHumansLung NeoplasmsMaleMetforminMorpholinesPhosphorylationProstatic NeoplasmsProtein Serine-Threonine KinasesPyrazolesPyrimidinesPyronesRNA, Small InterferingRadiation ToleranceTumor Suppressor Protein p53Tumor Suppressor Proteins