Journal article
Loss of Hepatocyte-Nuclear-Factor-1α Impacts on Adult Mouse Intestinal Epithelial Cell Growth and Cell Lineages Differentiation
Abstract
BACKGROUND AND AIMS: Although Hnf1alpha is crucial for pancreas and liver functions, it is believed to play a limited functional role for intestinal epithelial functions. The aim of this study was to assess the consequences of abrogating Hnf1alpha on the maintenance of adult small intestinal epithelial functions.
METHODOLOGY/PRINCIPAL FINDINGS: An Hnf1alpha knockout mouse model was used. Assessment of histological abnormalities, crypt …
Authors
Lussier CR; Brial F; Roy SAB; Langlois M-J; Verdu EF; Rivard N; Perreault N; Boudreau F
Journal
PLOS ONE, Vol. 5, No. 8,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0012378
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBiological TransportCell DifferentiationCell ProliferationEnterocytesEnteroendocrine CellsGene DeletionGene Knockout TechniquesGlucoseHepatocyte Nuclear Factor 1-alphaHomeostasisIntestinal MucosaIntracellular Signaling Peptides and ProteinsMicePaneth CellsProtein Serine-Threonine KinasesSignal TransductionTOR Serine-Threonine KinasesUp-Regulation