Journal article
The unfolded protein response is triggered following a single, unaccustomed resistance-exercise bout
Abstract
Endoplasmic reticulum (ER) stress results from an imbalance between the abundance of synthesized proteins and the folding capacity of the ER. In response, the unfolded protein response (UPR) attempts to restore ER function by attenuating protein synthesis and inducing chaperone expression. Resistance exercise (RE) stimulates protein synthesis; however, a postexercise accumulation of unfolded proteins may activate the UPR. Aging may impair …
Authors
Ogborn DI; McKay BR; Crane JD; Parise G; Tarnopolsky MA
Journal
AJP Regulatory Integrative and Comparative Physiology, Vol. 307, No. 6, pp. r664–r669
Publisher
American Physiological Society
Publication Date
September 15, 2014
DOI
10.1152/ajpregu.00511.2013
ISSN
0363-6119
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Activating Transcription Factor 4Activating Transcription Factor 6AdolescentAge FactorsAgedEndoplasmic ReticulumEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressEndoribonucleasesHeat-Shock ProteinsHumansMaleMuscle ContractionProtein Serine-Threonine KinasesQuadriceps MuscleRNA, MessengerResistance TrainingSignal TransductionTime FactorsTranscription Factor CHOPUnfolded Protein ResponseYoung AdulteIF-2 Kinase